Effect of 6,7-dimethoxy-2,2-dimethyl-2H-chromene (agerarin) on the Recovery of Filaggrin Expression Through Targeting of Janus Kinases in the Inflammatory Skin

Overview

Journal J Food Drug Anal

Specialties Nutritional Sciences
Pharmacology
Toxicology

Date 2022 Jun 13

PMID 35696096

Authors

Sung Shin Ahn

Young Han Lee

Hyunjin Yeo

Youngshim Lee

Do Sik Min

Yoongho Lim

Soon Young Shin

Affiliations

Soon will be listed here.

Abstract

Filaggrin (FLG) is a structural component of the stratum corneum that is essential for maintaining the barrier function of the skin and for the formation of natural moisturizing factors. 6,7-Dimethoxy-2,2-dimethyl-2H-chromene (Agerarin) is a bioactive compound derived from Ageratum houstonianum, a plant that is used as a traditional medicine to treat skin diseases. This study aimed to evaluate the effect of agerarin on skin inflammation in a dinitrochlorobenzene (DNCB)-induced atopic dermatitis mouse model. We found that the topical administration of agerarin ameliorates atopic dermatitis-like skin lesions. We also showed that agerarin restores the reduced filaggrin (FLG) expression in DNCB-applied skin sections. Moreover, agerarin decreased phosphorylation of JAK1 and JAK2 kinases to enhance FLG expression, which was reduced by TNFα+IFNγ and IL4+IL13 treatment, in HaCaT keratinocytes. These results demonstrate the feasibility of agerarin as a possible therapeutic against conditions of skin inflammation, such as atopic dermatitis, by improving the upregulation of FLG expression.

Citing Articles

Saikosaponin A Recovers Impaired Filaggrin Levels in Inflamed Skin by Downregulating the Expression of FRA1 and c-Jun.

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PMID: 39274912 PMC: 11396542. DOI: 10.3390/molecules29174064.

FRA1:c-JUN:HDAC1 complex down-regulates filaggrin expression upon TNFα and IFNγ stimulation in keratinocytes.

Ahn S, Yeo H, Jung E, Lim Y, Han Lee Y, Shin S Proc Natl Acad Sci U S A. 2022; 119(37):e2123451119.

PMID: 36067301 PMC: 9477237. DOI: 10.1073/pnas.2123451119.

The Natural Janus Kinase Inhibitor Agerarin Downregulates Interleukin-4-Induced Expression in HaCaT Keratinocytes.

Lee J, Jung E, Yeo H, Ahn S, Lim Y, Han Lee Y Molecules. 2022; 27(13).

PMID: 35807451 PMC: 9268509. DOI: 10.3390/molecules27134205.

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