Regulatory Role and Potential Importance of GDF-8 in Ovarian Reproductive Activity

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2022 Jun 13

PMID 35692411

Authors

Xiaoling Zheng

Yongquan Zheng

Dongxu Qin

Yao Yao

Xiao Zhang

Yunchun Zhao

Caihong Zheng

Affiliations

Soon will be listed here.

Abstract

Growth differentiation factor-8 (GDF-8) is a member of the transforming growth factor-beta superfamily. Studies and have shown GDF-8 to be involved in the physiology and pathology of ovarian reproductive functions. experiments using a granulosa-cell model have demonstrated steroidogenesis, gonadotrophin responsiveness, glucose metabolism, cell proliferation as well as expression of lysyl oxidase and pentraxin 3 to be regulated by GDF-8 the mothers against decapentaplegic homolog signaling pathway. Clinical data have shown that GDF-8 is expressed widely in the human ovary and has high expression in serum of obese women with polycystic ovary syndrome. GDF-8 expression in serum changes dynamically in patients undergoing controlled ovarian hyperstimulation. GDF-8 expression in serum and follicular fluid is correlated with the ovarian response and pregnancy outcome during fertilization. Blocking the GDF-8 signaling pathway is a potential therapeutic for ovarian hyperstimulation syndrome and ovulation disorders in polycystic ovary syndrome. GDF-8 has a regulatory role and potential importance in ovarian reproductive activity and may be involved in folliculogenesis, ovulation, and early embryo implantation.

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