Tissue-specific Proteasomes in Generation of MHC Class I Peptides and CD8 T Cells

Overview

Journal Curr Opin Immunol

Publisher Elsevier

Specialty Allergy & Immunology

Date 2022 Jun 11

PMID 35689940

Authors

Mami Matsuda-Lennikov

Izumi Ohigashi

Yousuke Takahama

Affiliations

Soon will be listed here.

Abstract

Thymoproteasomes and immunoproteasomes are two types of tissue-specific proteasomes, which contribute to the production of major histocompatibility complex (MHC) class I (MHC-I)-associated peptides that are important for the development and function of CD8 cytotoxic T cells. Thymoproteasomes are specifically expressed by cortical thymic epithelial cells and are important for MHC-I-dependent positive selection of developing thymocytes, whereas immunoproteasomes are abundant in many other cells, including hematopoietic cells and medullary thymic epithelial cells. Here we summarize the role of these two tissue-specific proteasomes, focusing on their functions in the development of CD8 T cells in the thymus.

Citing Articles

Identification of RNA-binding protein hnRNP C targeting the 3'UTR of the TAP-associated glycoprotein tapasin in melanoma.

Wang Y, Seliger B Oncoimmunology. 2024; 13(1):2370928.

PMID: 38948930 PMC: 11212565. DOI: 10.1080/2162402X.2024.2370928.

Autoimmune CD8+ T cells in type 1 diabetes: from single-cell RNA sequencing to T-cell receptor redirection.

Yang K, Zhang Y, Ding J, Li Z, Zhang H, Zou F Front Endocrinol (Lausanne). 2024; 15:1377322.

PMID: 38800484 PMC: 11116783. DOI: 10.3389/fendo.2024.1377322.

Immunoproteasomal Processing of IsoLG-Adducted Proteins Is Essential for Hypertension.

de la Visitacion N, Chen W, Krishnan J, Van Beusecum J, Amarnath V, Hennen E Circ Res. 2024; 134(10):1276-1291.

PMID: 38623763 PMC: 11081850. DOI: 10.1161/CIRCRESAHA.124.324068.

Killing capacity analysis of tumor-infiltrating cytotoxic lymphocytes and impact on lymph node metastasis in differentiated papillary carcinoma of thyroid with the BRAF V600E mutation.

Liu X, Liu H, Wang L, Han Y, Kong L, Zhang X Diagn Pathol. 2024; 19(1):29.

PMID: 38341587 PMC: 10858496. DOI: 10.1186/s13000-024-01454-9.

Cellular senescence-related genes: predicting prognosis in hepatocellular carcinoma.

Yuan W, Xu Y, Wu Z, Huang Y, Meng L, Dai S BMC Cancer. 2023; 23(1):1001.

PMID: 37853322 PMC: 10585749. DOI: 10.1186/s12885-023-11288-1.

References

Lich J, Elliott J, Blum J . Cytoplasmic processing is a prerequisite for presentation of an endogenous antigen by major histocompatibility complex class II proteins. J Exp Med. 2000; 191(9):1513-24. PMC: 2213437. DOI: 10.1084/jem.191.9.1513. View

Nitta T, Murata S, Sasaki K, Fujii H, Mat Ripen A, Ishimaru N . Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells. Immunity. 2010; 32(1):29-40. DOI: 10.1016/j.immuni.2009.10.009. View

Murata S, Takahama Y, Kasahara M, Tanaka K . The immunoproteasome and thymoproteasome: functions, evolution and human disease. Nat Immunol. 2018; 19(9):923-931. DOI: 10.1038/s41590-018-0186-z. View

Rock K, Farfan-Arribas D, Shen L . Proteases in MHC class I presentation and cross-presentation. J Immunol. 2009; 184(1):9-15. PMC: 3094101. DOI: 10.4049/jimmunol.0903399. View

Apavaloaei A, Laverdure J, Perreault C . PSMB11 regulates gene expression in cortical thymic epithelial cells. Cell Rep. 2021; 36(10):109546. DOI: 10.1016/j.celrep.2021.109546. View

Erath S, Groettrup M . No evidence for immunoproteasomes in chicken lymphoid organs and activated lymphocytes. Immunogenetics. 2014; 67(1):51-60. DOI: 10.1007/s00251-014-0814-1. View

Ohigashi I, Takahama Y . Thymoproteasome optimizes positive selection of CD8 T cells without contribution of negative selection. Adv Immunol. 2021; 149:1-23. PMC: 8237917. DOI: 10.1016/bs.ai.2021.03.001. View

Sakata M, Ohigashi I, Takahama Y . Cellularity of Thymic Epithelial Cells in the Postnatal Mouse. J Immunol. 2018; 200(4):1382-1388. DOI: 10.4049/jimmunol.1701235. View

Venables T, Griffith A, DeAraujo A, Petrie H . Dynamic changes in epithelial cell morphology control thymic organ size during atrophy and regeneration. Nat Commun. 2019; 10(1):4402. PMC: 6765001. DOI: 10.1038/s41467-019-11879-2. View

10.

Osterloh P, Linkemann K, Tenzer S, Rammensee H, Radsak M, Busch D . Proteasomes shape the repertoire of T cells participating in antigen-specific immune responses. Proc Natl Acad Sci U S A. 2006; 103(13):5042-7. PMC: 1458791. DOI: 10.1073/pnas.0509256103. View

11.

Kasahara M, Flajnik M . Origin and evolution of the specialized forms of proteasomes involved in antigen presentation. Immunogenetics. 2019; 71(3):251-261. PMC: 6377343. DOI: 10.1007/s00251-019-01105-0. View

12.

Magor K, Miranzo Navarro D, Barber M, Petkau K, Fleming-Canepa X, Blyth G . Defense genes missing from the flight division. Dev Comp Immunol. 2013; 41(3):377-88. PMC: 7172724. DOI: 10.1016/j.dci.2013.04.010. View

13.

Basler M, Mundt S, Groettrup M . The immunoproteasome subunit LMP7 is required in the murine thymus for filling up a hole in the T cell repertoire. Eur J Immunol. 2017; 48(3):419-429. DOI: 10.1002/eji.201747282. View

14.

Sasaki K, Takada K, Ohte Y, Kondo H, Sorimachi H, Tanaka K . Thymoproteasomes produce unique peptide motifs for positive selection of CD8(+) T cells. Nat Commun. 2015; 6:7484. PMC: 4557289. DOI: 10.1038/ncomms8484. View

15.

Xing Y, Jameson S, Hogquist K . Thymoproteasome subunit-β5T generates peptide-MHC complexes specialized for positive selection. Proc Natl Acad Sci U S A. 2013; 110(17):6979-84. PMC: 3637736. DOI: 10.1073/pnas.1222244110. View

16.

Hirakawa M, Nagakubo D, Kanzler B, Avilov S, Krauth B, Happe C . Fundamental parameters of the developing thymic epithelium in the mouse. Sci Rep. 2018; 8(1):11095. PMC: 6056470. DOI: 10.1038/s41598-018-29460-0. View

17.

Ohigashi I, Tanaka Y, Kondo K, Fujimori S, Kondo H, Palin A . Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells. Cell Rep. 2019; 29(9):2901-2916.e6. PMC: 6897492. DOI: 10.1016/j.celrep.2019.10.079. View

18.

Ohigashi I, Takahama Y . Specific impact of β5t on proteasome subunit composition in cortical thymic epithelial cells. Cell Rep. 2021; 36(10):109657. PMC: 8442848. DOI: 10.1016/j.celrep.2021.109657. View

19.

Murata S, Sasaki K, Kishimoto T, Niwa S, Hayashi H, Takahama Y . Regulation of CD8+ T cell development by thymus-specific proteasomes. Science. 2007; 316(5829):1349-53. DOI: 10.1126/science.1141915. View

20.

DE TOGNI P, Goellner J, Ruddle N, Streeter P, Fick A, Mariathasan S . Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science. 1994; 264(5159):703-7. DOI: 10.1126/science.8171322. View