Targeting Lipid Metabolism in Cancer: Neuroblastoma

Overview

Journal Cancer Metastasis Rev

Specialty Oncology

Date 2022 Jun 10

PMID 35687185

Authors

Massimiliano Agostini

Gerry Melino

Bola Habeb

Jorgelina M Calandria

Nicolas G Bazan

Affiliations

Soon will be listed here.

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References

Thiele C . Biology of pediatric peripheral neuroectodermal tumors. Cancer Metastasis Rev. 1991; 10(4):311-9. DOI: 10.1007/BF00554793. View

Pieraccioli M, Nicolai S, Pitolli C, Agostini M, Antonov A, Malewicz M . ZNF281 inhibits neuronal differentiation and is a prognostic marker for neuroblastoma. Proc Natl Acad Sci U S A. 2018; 115(28):7356-7361. PMC: 6048510. DOI: 10.1073/pnas.1801435115. View

Amelio I, Bertolo R, Bove P, Candi E, Chiocchi M, Cipriani C . Cancer predictive studies. Biol Direct. 2020; 15(1):18. PMC: 7557058. DOI: 10.1186/s13062-020-00274-3. View

Molenaar J, Koster J, Zwijnenburg D, van Sluis P, Valentijn L, van der Ploeg I . Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes. Nature. 2012; 483(7391):589-93. DOI: 10.1038/nature10910. View

Mosse Y, Laudenslager M, Longo L, Cole K, Wood A, Attiyeh E . Identification of ALK as a major familial neuroblastoma predisposition gene. Nature. 2008; 455(7215):930-5. PMC: 2672043. DOI: 10.1038/nature07261. View

De Laurenzi V, Melino G . Evolution of functions within the p53/p63/p73 family. Ann N Y Acad Sci. 2001; 926:90-100. DOI: 10.1111/j.1749-6632.2000.tb05602.x. View

Candi E, Terrinoni A, Rufini A, Chikh A, Lena A, Suzuki Y . p63 is upstream of IKK alpha in epidermal development. J Cell Sci. 2006; 119(Pt 22):4617-22. DOI: 10.1242/jcs.03265. View

Candi E, Cipollone R, Rivetti di Val Cervo P, Gonfloni S, Melino G, Knight R . p63 in epithelial development. Cell Mol Life Sci. 2008; 65(20):3126-33. PMC: 11131713. DOI: 10.1007/s00018-008-8119-x. View

Candi E, Agostini M, Melino G, Bernassola F . How the TP53 family proteins TP63 and TP73 contribute to tumorigenesis: regulators and effectors. Hum Mutat. 2014; 35(6):702-14. DOI: 10.1002/humu.22523. View

10.

Agostini M, Tucci P, Killick R, Candi E, Sayan B, Rivetti di Val Cervo P . Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets. Proc Natl Acad Sci U S A. 2011; 108(52):21093-8. PMC: 3248477. DOI: 10.1073/pnas.1112061109. View

11.

Tomasini R, Tsuchihara K, Tsuda C, Lau S, Wilhelm M, Rufini A . TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity. Proc Natl Acad Sci U S A. 2009; 106(3):797-802. PMC: 2621249. DOI: 10.1073/pnas.0812096106. View

12.

Amelio I, Melino G . The p53 family and the hypoxia-inducible factors (HIFs): determinants of cancer progression. Trends Biochem Sci. 2015; 40(8):425-34. DOI: 10.1016/j.tibs.2015.04.007. View

13.

Nepravishta R, Sabelli R, Iorio E, Micheli L, Paci M, Melino S . Oxidative species and S-glutathionyl conjugates in the apoptosis induction by allyl thiosulfate. FEBS J. 2011; 279(1):154-67. DOI: 10.1111/j.1742-4658.2011.08407.x. View

14.

Mauretti A, Neri A, Kossover O, Seliktar D, Nardo P, Melino S . Design of a Novel Composite H2 S-Releasing Hydrogel for Cardiac Tissue Repair. Macromol Biosci. 2016; 16(6):847-58. DOI: 10.1002/mabi.201500430. View

15.

Hattori T, Takahashi Y, Chen L, Tang Z, Wills C, Liang X . Targeting the ESCRT-III component CHMP2A for noncanonical Caspase-8 activation on autophagosomal membranes. Cell Death Differ. 2020; 28(2):657-670. PMC: 7862398. DOI: 10.1038/s41418-020-00610-0. View

16.

Dang C, Reddy E, Shokat K, Soucek L . Drugging the 'undruggable' cancer targets. Nat Rev Cancer. 2017; 17(8):502-508. PMC: 5945194. DOI: 10.1038/nrc.2017.36. View

17.

Gouw A, Margulis K, Liu N, Raman S, Mancuso A, Toal G . The MYC Oncogene Cooperates with Sterol-Regulated Element-Binding Protein to Regulate Lipogenesis Essential for Neoplastic Growth. Cell Metab. 2019; 30(3):556-572.e5. PMC: 6911354. DOI: 10.1016/j.cmet.2019.07.012. View

18.

DeBerardinis R, Chandel N . Fundamentals of cancer metabolism. Sci Adv. 2016; 2(5):e1600200. PMC: 4928883. DOI: 10.1126/sciadv.1600200. View

19.

Lindner A, Salvucci M, McDonough E, Cho S, Stachtea X, OConnell E . An atlas of inter- and intra-tumor heterogeneity of apoptosis competency in colorectal cancer tissue at single-cell resolution. Cell Death Differ. 2021; 29(4):806-817. PMC: 8990071. DOI: 10.1038/s41418-021-00895-9. View

20.

Rosa N, Ivanova H, Wagner 2nd L, Kale J, La Rovere R, Welkenhuyzen K . Bcl-xL acts as an inhibitor of IPR channels, thereby antagonizing Ca-driven apoptosis. Cell Death Differ. 2021; 29(4):788-805. PMC: 8990011. DOI: 10.1038/s41418-021-00894-w. View