Vitamin D Metabolite Ratio in Pregnant Women with Low Blood Vitamin D Concentrations Is Associated with Neonatal Anthropometric Data

Overview

Journal Nutrients

Date 2022 Jun 10

PMID 35684001

Authors

Tomozumi Takatani

Yuzuka Kunii

Mamoru Satoh

Akifumi Eguchi

Midori Yamamoto

Kenichi Sakurai

Rieko Takatani

Fumio Nomura

Naoki Shimojo

Chisato Mori

Affiliations

Soon will be listed here.

Abstract

Existing evidence on the correlation between maternal vitamin D concentrations and birth outcomes is conflicting. Investigation of these associations requires accurate assessment of vitamin D status, especially in individuals with low 25-hydroxyvitamin D (25(OH)D) concentrations. This study examined the correlations between birth outcomes and the maternal vitamin D metabolite ratio (VMR) 1 (defined as the ratio of 24,25(OH)D to 25(OH)D) and VMR2 (defined as the ratio of 3-epi-25(OH)D to 25(OH)D) using data from the Japan Environment and Children's Study at Chiba Regional Center. A total of 297 mother-neonate pairs were analyzed. Using liquid chromatography-tandem mass spectrometry, we measured 25(OH)D, 25(OH)D, 24,25(OH)D, and 3-epi-25(OH)D concentrations in maternal serum samples. These data were analyzed in relation to birth anthropometric data using multivariable linear regression. Of the study participants, 85.2% showed insufficient vitamin D concentrations. VMR1 was strongly correlated with 25(OH)D concentrations, whereas VMR2 showed a weak correlation. Only VMR2 was associated with all anthropometric data. VMR2 in pregnant women with low vitamin D blood concentrations is a useful marker for neonatal anthropometric data and is independent of 25(OH)D. Accurate measurement of vitamin D metabolites could help better understand the effects of vitamin D on birth outcomes.

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