The Role of Antibodies in the Treatment of SARS-CoV-2 Virus Infection, and Evaluating Their Contribution to Antibody-Dependent Enhancement of Infection

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 Jun 10

PMID 35682757

Authors

Mohammed A H Farouq

Reinaldo Acevedo

Valerie A Ferro

Paul A Mulheran

Mohammed M Al Qaraghuli

Affiliations

Soon will be listed here.

Abstract

Antibodies play a crucial role in the immune response, in fighting off pathogens as well as helping create strong immunological memory. Antibody-dependent enhancement (ADE) occurs when non-neutralising antibodies recognise and bind to a pathogen, but are unable to prevent infection, and is widely known and is reported as occurring in infection caused by several viruses. This narrative review explores the ADE phenomenon, its occurrence in viral infections and evaluates its role in infection by SARS-CoV-2 virus, which causes coronavirus disease 2019 (COVID-19). As of yet, there is no clear evidence of ADE in SARS-CoV-2, though this area is still subject to further study.

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References

Alsaadi E, Jones I . Membrane binding proteins of coronaviruses. Future Virol. 2020; 14(4):275-286. PMC: 7079996. DOI: 10.2217/fvl-2018-0144. View

Joyner M, Bruno K, Klassen S, Kunze K, Johnson P, Lesser E . Safety Update: COVID-19 Convalescent Plasma in 20,000 Hospitalized Patients. Mayo Clin Proc. 2020; 95(9):1888-1897. PMC: 7368917. DOI: 10.1016/j.mayocp.2020.06.028. View

Yip M, Leung H, Li P, Cheung C, Dutry I, Li D . Antibody-dependent enhancement of SARS coronavirus infection and its role in the pathogenesis of SARS. Hong Kong Med J. 2016; 22(3 Suppl 4):25-31. View

Tian X, Li C, Huang A, Xia S, Lu S, Shi Z . Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody. Emerg Microbes Infect. 2020; 9(1):382-385. PMC: 7048180. DOI: 10.1080/22221751.2020.1729069. View

Robbiani D, Gaebler C, Muecksch F, Lorenzi J, Wang Z, Cho A . Convergent antibody responses to SARS-CoV-2 in convalescent individuals. Nature. 2020; 584(7821):437-442. PMC: 7442695. DOI: 10.1038/s41586-020-2456-9. View

Mimoto F, Katada H, Kadono S, Igawa T, Kuramochi T, Muraoka M . Engineered antibody Fc variant with selectively enhanced FcγRIIb binding over both FcγRIIa(R131) and FcγRIIa(H131). Protein Eng Des Sel. 2013; 26(10):589-98. PMC: 3785249. DOI: 10.1093/protein/gzt022. View

Farouq M, Al Qaraghuli M, Kubiak-Ossowska K, Ferro V, Mulheran P . Biomolecular interactions with nanoparticles: applications for coronavirus disease 2019. Curr Opin Colloid Interface Sci. 2021; 54:101461. PMC: 8062422. DOI: 10.1016/j.cocis.2021.101461. View

Stanifer M, Kee C, Cortese M, Zumaran C, Triana S, Mukenhirn M . Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells. Cell Rep. 2020; 32(1):107863. PMC: 7303637. DOI: 10.1016/j.celrep.2020.107863. View

Diamond M, Edgil D, Roberts T, Lu B, Harris E . Infection of human cells by dengue virus is modulated by different cell types and viral strains. J Virol. 2000; 74(17):7814-23. PMC: 112311. DOI: 10.1128/jvi.74.17.7814-7823.2000. View

10.

Garg H, Yeh R, Watts D, Mehmetoglu-Gurbuz T, Resendes R, Parsons B . Enhancement of Zika virus infection by antibodies from West Nile virus seropositive individuals with no history of clinical infection. BMC Immunol. 2021; 22(1):5. PMC: 7796652. DOI: 10.1186/s12865-020-00389-2. View

11.

Lambert L, Culley F . Innate Immunity to Respiratory Infection in Early Life. Front Immunol. 2017; 8:1570. PMC: 5694434. DOI: 10.3389/fimmu.2017.01570. View

12.

Mohsin S, Mahmood S, Amar A, Ghafoor F, Raza S, Saleem M . Association of FcγRIIa Polymorphism with Clinical Outcome of Dengue Infection: First Insight from Pakistan. Am J Trop Med Hyg. 2015; 93(4):691-6. PMC: 4596583. DOI: 10.4269/ajtmh.15-0199. View

13.

Joyner M, Wright R, Fairweather D, Senefeld J, Bruno K, Klassen S . Early safety indicators of COVID-19 convalescent plasma in 5000 patients. J Clin Invest. 2020; 130(9):4791-4797. PMC: 7456238. DOI: 10.1172/JCI140200. View

14.

Okuya K, Hattori T, Saito T, Takadate Y, Sasaki M, Furuyama W . Multiple Routes of Antibody-Dependent Enhancement of SARS-CoV-2 Infection. Microbiol Spectr. 2022; 10(2):e0155321. PMC: 9045191. DOI: 10.1128/spectrum.01553-21. View

15.

Bournazos S, DiLillo D, Goff A, Glass P, Ravetch J . Differential requirements for FcγR engagement by protective antibodies against Ebola virus. Proc Natl Acad Sci U S A. 2019; 116(40):20054-20062. PMC: 6778250. DOI: 10.1073/pnas.1911842116. View

16.

Zhao F, Qu J, Wang W, Li S, Xu S . The imbalance of Th1/Th2 triggers an inflammatory response in chicken spleens after ammonia exposure. Poult Sci. 2020; 99(8):3817-3822. PMC: 7598003. DOI: 10.1016/j.psj.2020.04.029. View

17.

Weiss R, Scott F . Antibody-mediated enhancement of disease in feline infectious peritonitis: comparisons with dengue hemorrhagic fever. Comp Immunol Microbiol Infect Dis. 1981; 4(2):175-89. PMC: 7134169. DOI: 10.1016/0147-9571(81)90003-5. View

18.

Halwe S, Kupke A, Vanshylla K, Liberta F, Gruell H, Zehner M . Intranasal Administration of a Monoclonal Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection. Viruses. 2021; 13(8). PMC: 8402634. DOI: 10.3390/v13081498. View

19.

Kam Y, Kien F, Roberts A, Cheung Y, Lamirande E, Vogel L . Antibodies against trimeric S glycoprotein protect hamsters against SARS-CoV challenge despite their capacity to mediate FcgammaRII-dependent entry into B cells in vitro. Vaccine. 2006; 25(4):729-40. PMC: 7115629. DOI: 10.1016/j.vaccine.2006.08.011. View

20.

Wen J, Tang W, Sheets N, Ellison J, Sette A, Kim K . Identification of Zika virus epitopes reveals immunodominant and protective roles for dengue virus cross-reactive CD8 T cells. Nat Microbiol. 2017; 2:17036. PMC: 5918137. DOI: 10.1038/nmicrobiol.2017.36. View