Biomolecular Interactions with Nanoparticles: Applications for Coronavirus Disease 2019

Overview

Journal Curr Opin Colloid Interface Sci

Publisher Current Science

Specialty Chemistry

Date 2021 Apr 28

PMID 33907504

Citations 4

Authors

Mohammed A H Farouq

Mohammed M Al Qaraghuli

Karina Kubiak-Ossowska

Valerie A Ferro

Paul A Mulheran

Affiliations

Soon will be listed here.

Abstract

Nanoparticles are small particles sized 1-100 nm, which have a large surface-to-volume ratio, allowing efficient adsorption of drugs, proteins, and other chemical compounds. Consequently, functionalized nanoparticles have potential diagnostic and therapeutic applications. A variety of nanoparticles have been studied, including those constructed from inorganic materials, biopolymers, and lipids. In this review, we focus on recent work targeting the severe acute respiratory syndrome coronavirus 2 virus that causes coronavirus disease (COVID-19). Understanding the interactions between coronavirus-specific proteins (such as the spike protein and its host cell receptor angiotensin-converting enzyme 2) with different nanoparticles paves the way to the development of new therapeutics and diagnostics that are urgently needed for the fight against COVID-19, and indeed for related future viral threats that may emerge.

Citing Articles

Exploiting the Fc base of IgG antibodies to create functional nanoparticle conjugates.

Al Qaraghuli M, Kubiak-Ossowska K, Ferro V, Mulheran P Sci Rep. 2024; 14(1):14832.

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Biogenic Selenium Nanoparticles in Biomedical Sciences: Properties, Current Trends, Novel Opportunities and Emerging Challenges in Theranostic Nanomedicine.

Zambonino M, Quizhpe E, Mouheb L, Rahman A, Agathos S, Dahoumane S Nanomaterials (Basel). 2023; 13(3).

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The Role of Antibodies in the Treatment of SARS-CoV-2 Virus Infection, and Evaluating Their Contribution to Antibody-Dependent Enhancement of Infection.

Farouq M, Acevedo R, Ferro V, Mulheran P, Al Qaraghuli M Int J Mol Sci. 2022; 23(11).

PMID: 35682757 PMC: 9181534. DOI: 10.3390/ijms23116078.

Editorial Overview: Hot Topic: COVID-19: Colloid and Interface Aspects of COVID-19.

Liggieri L, Miller R Curr Opin Colloid Interface Sci. 2021; 56:101525.

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