Effects of Morphine on Cardiovascular Responses to Acute Myocardial Ischaemia in Rats

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1987 Mar 1

PMID 3567459

Citations 5

Authors

M Y Chan

S Dai

W W Ko

Affiliations

Soon will be listed here.

Abstract

The effects of acute coronary artery ligation on cardiac rhythm and haemodynamics were studied in rats receiving either acute or chronic morphine-treatment. In chronic opiate-treated animals, increasing concentrations of morphine sulphate were administered in drinking water over a 3 week period, and the development of morphine tolerance and dependence was verified by decreased analgesic responses to morphine in the tail-immersion test and the occurrence of naloxone-precipitated withdrawal syndromes, respectively. Acute coronary artery ligation induced a decrease in blood pressure, a slight increase in heart rate, and ventricular tachycardia or fibrillation in anaesthetized rats. The changes in blood pressure and heart rate following acute coronary artery ligation were not significantly altered by acute or chronic morphine administration. The incidence and the time of onset of ventricular tachycardia or fibrillation were found to be significantly reduced and prolonged, respectively, in chronically morphine-treated rats, but were not significantly affected by acute morphine administration in naïve animals. These findings suggest that chronic morphine treatment lessens the occurrence of early ventricular arrhythmias caused by acute myocardial ischaemia in rats. The mechanism of this effect is unclear.

Citing Articles

Ventricular histamine concentrations in naive and morphine-treated rats during acute myocardial ischaemia.

Ko W, Dai S, Chan M Agents Actions. 1988; 24(1-2):95-101.

PMID: 3407556 DOI: 10.1007/BF01968085.

Ventricular noradrenaline concentrations in naïve and morphine-treated rats subjected to acute myocardial ischaemia.

Ko W, Dai S, Chan M Br J Pharmacol. 1988; 93(4):723-8.

PMID: 3390648 PMC: 1853892. DOI: 10.1111/j.1476-5381.1988.tb11455.x.

Arterial catecholamine levels in morphine-treated rats subjected to sympathetic nerve stimulation.

Leung C, Dai S, Ogle C Br J Pharmacol. 1989; 96(4):888-94.

PMID: 2743083 PMC: 1854453. DOI: 10.1111/j.1476-5381.1989.tb11899.x.

Acute hemodynamic effects of coronary artery ligation in conscious rats.

Schoemaker R, Urquhart J, Debets J, Struyker Boudier H, Smits J Basic Res Cardiol. 1990; 85(1):9-20.

PMID: 2327951 DOI: 10.1007/BF01907010.

Changes in preganglionic sympathetic nerve function following chronic morphine treatment in rats.

Leung C, Dai S, Ogle C Br J Pharmacol. 1990; 99(2):247-52.

PMID: 1970267 PMC: 1917369. DOI: 10.1111/j.1476-5381.1990.tb14689.x.

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