The Impact of Zinc Supplementation on Galectin-3 and Metabolic Markers in Diabetic Patients on Hemodialysis: A Randomized, Double-blind, Placebo-controlled Trial

Overview

Journal J Diabetes Metab Disord

Specialty Endocrinology

Date 2022 Jun 8

PMID 35673488

Authors

Razieh Hosseini

Mansour Karajibani

Farzaneh Montazerifar

Elham Shahraki

Khatereh Babakhani

Ali Mohammad Mokhtari

Amirhossein Sahebkar

Affiliations

Soon will be listed here.

Abstract

Purpose: There is little information about the association between zinc sulfate (ZnSO4) supplementation and metabolic profiles in zinc-deficient diabetic patients on hemodialysis (DHPs). Therefore, we aimed to investigate the association between ZnSO4 supplementation and serum levels of galectin-3 (Gal-3) and cardiometabolic parameters in zinc-deficient DHPs.

Methods: In the present randomized double-blind placebo-controlled clinical trial, 46 zinc-deficient DHPs (35-62 years) were included and assigned to receive either 220 mg/d ZnSO4 or placebo for 8 weeks. Serum levels of Gal-3, lipid profile, and blood pressure (BP) were assessed at baseline and the end of trial.

Results: We found a significant effect of ZnSO4 intake on the reduction of serum Gal-3 ( = < 0.001), triglycerides ( = < 0.001), total cholesterol ( = < 0.001), low-density lipoprotein cholesterol ( = < 0.001) and increased high-density lipoprotein cholesterol ( = < 0.001) as compared to the control group. Additionally, systolic blood pressure (SBP) ( = 0.006) and diastolic blood pressure (DBP) ( = 0.01) were significantly reduced following 8 weeks of ZnSO4 supplementation.

Conclusion: Taken together, 220 mg ZnSO4 supplementation per day for 8 weeks among zinc-deficient DHPs had beneficial effects on Gal-3 and metabolic profiles.

Iranian Registry Of Clinical Trials Identifier: IRCT20191217045765N1, date of registration: 2020-02-09.

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