Construction of Nanocarriers Based on Nucleic Acids and Their Applications in Nanobiology Delivery Systems

Overview

Journal Natl Sci Rev

Date 2022 Jun 7

PMID 35668748

Authors

Yingshu Guo

Xiuping Cao

Xiaofei Zheng

S K Jahir Abbas

Juan Li

Weihong Tan

Affiliations

Soon will be listed here.

Abstract

In recent years, nanocarriers based on nucleic acids have emerged as powerful and novel nanocarriers that are able to meet the demand for cancer-cell-specific targeting. Functional dynamics analysis revealed good biocompatibility, low toxicity and programmable structures, and their advantages include controllable size and modifiability. The development of novel hybrids has focused on the distinct roles of biosensing, drug and gene delivery, vaccine transport, photosensitization, counteracting drug resistance and functioning as carriers and logic gates. This review is divided into three parts: (i) DNA nanocarriers, (ii) RNA nanocarriers and (iii) DNA/RNA hybrid nanocarriers and their applications in nanobiology delivery systems. We also provide perspectives on possible future directions for growth in this field.

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References

Wang Y, Shang X, Liu J, Guo Y . ATP mediated rolling circle amplification and opening DNA-gate for drug delivery to cell. Talanta. 2017; 176:652-658. DOI: 10.1016/j.talanta.2017.08.087. View

Zhu G, Mei L, Vishwasrao H, Jacobson O, Wang Z, Liu Y . Intertwining DNA-RNA nanocapsules loaded with tumor neoantigens as synergistic nanovaccines for cancer immunotherapy. Nat Commun. 2017; 8(1):1482. PMC: 5684198. DOI: 10.1038/s41467-017-01386-7. View

Zhang S, Zhi D, Huang L . Lipid-based vectors for siRNA delivery. J Drug Target. 2012; 20(9):724-35. PMC: 5006685. DOI: 10.3109/1061186X.2012.719232. View

Lee D, Qian H, Tay C, Leong D . Cellular processing and destinies of artificial DNA nanostructures. Chem Soc Rev. 2016; 45(15):4199-225. DOI: 10.1039/c5cs00700c. View

Sayour E, Grippin A, De Leon G, Stover B, Rahman M, Karachi A . Personalized Tumor RNA Loaded Lipid-Nanoparticles Prime the Systemic and Intratumoral Milieu for Response to Cancer Immunotherapy. Nano Lett. 2018; 18(10):6195-6206. PMC: 6597257. DOI: 10.1021/acs.nanolett.8b02179. View

Zhang P, Gao D, An K, Shen Q, Wang C, Zhang Y . A programmable polymer library that enables the construction of stimuli-responsive nanocarriers containing logic gates. Nat Chem. 2020; 12(4):381-390. DOI: 10.1038/s41557-020-0426-3. View

Pan Q, Nie C, Hu Y, Yi J, Liu C, Zhang J . Aptamer-Functionalized DNA Origami for Targeted Codelivery of Antisense Oligonucleotides and Doxorubicin to Enhance Therapy in Drug-Resistant Cancer Cells. ACS Appl Mater Interfaces. 2019; 12(1):400-409. DOI: 10.1021/acsami.9b20707. View

Li B, Setyawati M, Chen L, Xie J, Ariga K, Lim C . Directing Assembly and Disassembly of 2D MoS Nanosheets with DNA for Drug Delivery. ACS Appl Mater Interfaces. 2017; 9(18):15286-15296. DOI: 10.1021/acsami.7b02529. View

Aji Alex M, Nehate C, Veeranarayanan S, Kumar D, Kulshreshtha R, Koul V . Self assembled dual responsive micelles stabilized with protein for co-delivery of drug and siRNA in cancer therapy. Biomaterials. 2017; 133:94-106. DOI: 10.1016/j.biomaterials.2017.04.022. View

10.

Khaled S, Cevenini A, Yazdi I, Parodi A, Evangelopoulos M, Corbo C . One-pot synthesis of pH-responsive hybrid nanogel particles for the intracellular delivery of small interfering RNA. Biomaterials. 2016; 87:57-68. PMC: 4785811. DOI: 10.1016/j.biomaterials.2016.01.052. View

11.

Bousmail D, Amrein L, Fakhoury J, Fakih H, Hsu J, Panasci L . Precision spherical nucleic acids for delivery of anticancer drugs. Chem Sci. 2017; 8(9):6218-6229. PMC: 5628336. DOI: 10.1039/c7sc01619k. View

12.

Kong F, Zhang H, Qu X, Zhang X, Chen D, Ding R . Gold Nanorods, DNA Origami, and Porous Silicon Nanoparticle-functionalized Biocompatible Double Emulsion for Versatile Targeted Therapeutics and Antibody Combination Therapy. Adv Mater. 2016; 28(46):10195-10203. DOI: 10.1002/adma.201602763. View

13.

Luo X, Li Z, Wang G, He X, Shen X, Sun Q . MicroRNA-Catalyzed Cancer Therapeutics Based on DNA-Programmed Nanoparticle Complex. ACS Appl Mater Interfaces. 2017; 9(39):33624-33631. DOI: 10.1021/acsami.7b09420. View

14.

Yoshizaki Y, Yuba E, Sakaguchi N, Koiwai K, Harada A, Kono K . pH-sensitive polymer-modified liposome-based immunity-inducing system: Effects of inclusion of cationic lipid and CpG-DNA. Biomaterials. 2017; 141:272-283. DOI: 10.1016/j.biomaterials.2017.07.001. View

15.

Hong S, Zhang M, Zhang M, Yu Y, Chen J, Zhang X . Follicle-stimulating hormone peptide-conjugated nanoparticles for targeted shRNA delivery lead to effective gro-α silencing and antitumor activity against ovarian cancer. Drug Deliv. 2018; 25(1):576-584. PMC: 6058603. DOI: 10.1080/10717544.2018.1440667. View

16.

Varshney A, Panda J, Singh A, Yadav N, Bihari C, Biswas S . Targeted delivery of microRNA-199a-3p using self-assembled dipeptide nanoparticles efficiently reduces hepatocellular carcinoma in mice. Hepatology. 2017; 67(4):1392-1407. DOI: 10.1002/hep.29643. View

17.

Zhou F, Wang P, Peng Y, Zhang P, Huang Q, Sun W . Molecular Engineering-Based Aptamer-Drug Conjugates with Accurate Tunability of Drug Ratios for Drug Combination Targeted Cancer Therapy. Angew Chem Int Ed Engl. 2019; 58(34):11661-11665. DOI: 10.1002/anie.201903807. View

18.

Wang Y, Yu C . Emerging Concepts of Nanobiotechnology in mRNA Delivery. Angew Chem Int Ed Engl. 2020; 59(52):23374-23385. DOI: 10.1002/anie.202003545. View

19.

Zhou X, Li H, He M, Yin X, Yao D, Xiao S . Photoresponsive spherical nucleic acid: spatiotemporal control of the assembly circuit and intracellular microRNA release. Chem Commun (Camb). 2017; 54(1):106-109. DOI: 10.1039/c7cc07932j. View

20.

Kedmi R, Veiga N, Ramishetti S, Goldsmith M, Rosenblum D, Dammes N . A modular platform for targeted RNAi therapeutics. Nat Nanotechnol. 2018; 13(3):214-219. DOI: 10.1038/s41565-017-0043-5. View