A Route to Lipid ALC-0315: a Key Component of a COVID-19 MRNA Vaccine

Overview

Journal Chemistry

Specialty Chemistry

Date 2022 Jun 6

PMID 35665545

Authors

Fariba Saadati

Silvia Cammarone

Marco A Ciufolini

Affiliations

Soon will be listed here.

Abstract

This paper describes a synthesis of ALC-0315 by a sequence that more than doubles the overall yield relative to the published one, and that employs much cleaner reactions, thereby facilitating purifications to a considerable extent.

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Saadati F, Cammarone S, Ciufolini M . A Route to Lipid ALC-0315: a Key Component of a COVID-19 mRNA Vaccine. Chemistry. 2022; 28(48):e202200906. PMC: 9348069. DOI: 10.1002/chem.202200906. View