A Catalog of 48,425 Nonredundant Viruses from Oral Metagenomes Expands the Horizon of the Human Oral Virome

Overview

Journal iScience

Publisher Cell Press

Date 2022 Jun 6

PMID 35663034

Authors

Shenghui Li

Ruochun Guo

Yue Zhang

Peng Li

Fang Chen

Xifan Wang

Jing Li

Zhuye Jie

Qingbo Lv

Hao Jin

Guangyang Wang

Qiulong Yan

Affiliations

Soon will be listed here.

Abstract

The human oral cavity is a hotspot of numerous, mostly unexplored, viruses that are important for maintaining oral health and microbiome homeostasis. Here, we analyzed 2,792 publicly available oral metagenomes and proposed the Oral Virus Database (OVD) comprising 48,425 nonredundant viral genomes (≥5 kbp). The OVD catalog substantially expanded the known phylogenetic diversity and host specificity of oral viruses, allowing for enhanced delineation of some underrepresented groups such as the predicted phages and jumbo viruses. Comparisons of the viral diversity and abundance of different oral cavity habitats suggested strong niche specialization of viromes within individuals. The virome variations in relation to host geography and properties were further uncovered, especially the age-dependent viral compositional signatures in saliva. Overall, the viral genome catalog describes the architecture and variability of the human oral virome, while offering new resources and insights for current and future studies.

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