The Progress of the Prevention and Treatment of Vitamin D to Tuberculosis

Overview

Journal Front Nutr

Specialty Nutritional Sciences

Date 2022 Jun 6

PMID 35662926

Authors

Li Cai

Gaoming Wang

Peijun Zhang

Xinyi Hu

Hao Zhang

Fan Wang

Yeqing Tong

Affiliations

Soon will be listed here.

Abstract

The progressions of a number of lung diseases, including acute lung injury, cystic fibrosis, asthma, chronic obstructive pulmonary disease, pneumonia and tuberculosis (TB) are found to be highly associated with inflammatory responses. As a signaling nutrient, Vitamin D modulates the activities of dendritic cells, monocytes/macrophages, T and B cells, and tissue epithelial cells in the body to induce inflammatory responses and boost immune functions. Given the high prevalence of vitamin D deficiency among pulmonary insufficiency and inflammation-related cases, researchers indicated vitamin D supplementation could have a potential role in the prevention and treatment of lung disease, especially tuberculosis. In this paper, we reviewed published studies on the role of vitamin D in the prevention and treatment of tuberculosis. The paper identified vitamin D's potential as an adjunctive therapy and demonstrated its safety so as to provide an impetus for further studies and clinical applications.

References

Chan T . Vitamin D deficiency and susceptibility to tuberculosis. Calcif Tissue Int. 2000; 66(6):476-8. DOI: 10.1007/s002230010095. View

Sutaria N, Liu C, Chen T . Vitamin D Status, Receptor Gene Polymorphisms, and Supplementation on Tuberculosis: A Systematic Review of Case-Control Studies and Randomized Controlled Trials. J Clin Transl Endocrinol. 2015; 1(4):151-160. PMC: 4295520. DOI: 10.1016/j.jcte.2014.08.001. View

Nnoaham K, Clarke A . Low serum vitamin D levels and tuberculosis: a systematic review and meta-analysis. Int J Epidemiol. 2008; 37(1):113-9. DOI: 10.1093/ije/dym247. View

Salahuddin N, Ali F, Hasan Z, Rao N, Aqeel M, Mahmood F . Vitamin D accelerates clinical recovery from tuberculosis: results of the SUCCINCT Study [Supplementary Cholecalciferol in recovery from tuberculosis]. A randomized, placebo-controlled, clinical trial of vitamin D supplementation in patients with.... BMC Infect Dis. 2013; 13:22. PMC: 3556334. DOI: 10.1186/1471-2334-13-22. View

Martineau A, Nanzer A, Satkunam K, Packe G, Rainbow S, Maunsell Z . Influence of a single oral dose of vitamin D(2) on serum 25-hydroxyvitamin D concentrations in tuberculosis patients. Int J Tuberc Lung Dis. 2008; 13(1):119-25. View

Rathored J, Sharma S, Singh B, Banavaliker J, Sreenivas V, Srivastava A . Risk and outcome of multidrug-resistant tuberculosis: vitamin D receptor polymorphisms and serum 25(OH)D. Int J Tuberc Lung Dis. 2012; 16(11):1522-8. DOI: 10.5588/ijtld.12.0122. View

Rivas-Santiago B, Serrano C, Enciso-Moreno J . Susceptibility to infectious diseases based on antimicrobial peptide production. Infect Immun. 2009; 77(11):4690-5. PMC: 2772553. DOI: 10.1128/IAI.01515-08. View

Khammissa R, Fourie J, Motswaledi M, Ballyram R, Lemmer J, Feller L . The Biological Activities of Vitamin D and Its Receptor in Relation to Calcium and Bone Homeostasis, Cancer, Immune and Cardiovascular Systems, Skin Biology, and Oral Health. Biomed Res Int. 2018; 2018:9276380. PMC: 5987305. DOI: 10.1155/2018/9276380. View

Hunter R . The Pathogenesis of Tuberculosis: The Early Infiltrate of Post-primary (Adult Pulmonary) Tuberculosis: A Distinct Disease Entity. Front Immunol. 2018; 9:2108. PMC: 6156532. DOI: 10.3389/fimmu.2018.02108. View

10.

Stern P, Taylor A, Bell N, Epstein S . Demonstration that circulating 1 alpha, 25-dihydroxyvitamin D is loosely regulated in normal children. J Clin Invest. 1981; 68(5):1374-7. PMC: 370935. DOI: 10.1172/jci110386. View

11.

Gwinup G, Randazzo G, Elias A . The influence of vitamin D intake on serum calcium in tuberculosis. Acta Endocrinol (Copenh). 1981; 97(1):114-7. DOI: 10.1530/acta.0.0970114. View

12.

Yousefzadeh P, Shapses S, Wang X . Vitamin D Binding Protein Impact on 25-Hydroxyvitamin D Levels under Different Physiologic and Pathologic Conditions. Int J Endocrinol. 2014; 2014:981581. PMC: 4020458. DOI: 10.1155/2014/981581. View

13.

Tjellesen L, Hummer L, Christiansen C, RODBRO P . Serum concentration of vitamin D metabolites during treatment with vitamin D2 and D3 in normal premenopausal women. Bone Miner. 1986; 1(5):407-13. View

14.

Kalousova M, Dusilova-Sulkova S, Zakiyanov O, Kostirova M, Safranek R, Tesar V . Vitamin D Binding Protein Is Not Involved in Vitamin D Deficiency in Patients with Chronic Kidney Disease. Biomed Res Int. 2015; 2015:492365. PMC: 4434169. DOI: 10.1155/2015/492365. View

15.

Wejse C, Gomes V, Rabna P, Gustafson P, Aaby P, Lisse I . Vitamin D as supplementary treatment for tuberculosis: a double-blind, randomized, placebo-controlled trial. Am J Respir Crit Care Med. 2009; 179(9):843-50. DOI: 10.1164/rccm.200804-567OC. View

16.

Reijven P, Soeters P . Vitamin D: A magic bullet or a myth?. Clin Nutr. 2020; 39(9):2663-2674. DOI: 10.1016/j.clnu.2019.12.028. View

17.

Talat N, Perry S, Parsonnet J, Dawood G, Hussain R . Vitamin d deficiency and tuberculosis progression. Emerg Infect Dis. 2010; 16(5):853-5. PMC: 2954005. DOI: 10.3201/eid1605.091693. View

18.

Jahnavi G, Sudha C . Randomised controlled trial of food supplements in patients with newly diagnosed tuberculosis and wasting. Singapore Med J. 2011; 51(12):957-62. View

19.

Pilz S, Marz W, Cashman K, Kiely M, Whiting S, Holick M . Rationale and Plan for Vitamin D Food Fortification: A Review and Guidance Paper. Front Endocrinol (Lausanne). 2018; 9:373. PMC: 6056629. DOI: 10.3389/fendo.2018.00373. View

20.

Sato S, Tanino Y, Saito J, Nikaido T, Inokoshi Y, Fukuhara A . Relationship between 25-hydroxyvitamin D levels and treatment course of pulmonary tuberculosis. Respir Investig. 2012; 50(2):40-5. DOI: 10.1016/j.resinv.2012.05.002. View