Insights into the Biology of IL-9 in Asthma

Overview

Journal J Allergy Clin Immunol

Specialty Allergy & Immunology

Date 2022 Jun 6

PMID 35662655

Authors

Taylor A Doherty

David H Broide

Affiliations

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References

Shimbara A, Christodoulopoulos P, Olivenstein R, Nakamura Y, Levitt R, Nicolaides N . IL-9 and its receptor in allergic and nonallergic lung disease: increased expression in asthma. J Allergy Clin Immunol. 2000; 105(1 Pt 1):108-15. DOI: 10.1016/s0091-6749(00)90185-4. View

Chakraborty S, Kubatzky K, Mitra D . An Update on Interleukin-9: From Its Cellular Source and Signal Transduction to Its Role in Immunopathogenesis. Int J Mol Sci. 2019; 20(9). PMC: 6522352. DOI: 10.3390/ijms20092113. View

Parker J, Oh C, LaForce C, Miller S, Pearlman D, Le C . Safety profile and clinical activity of multiple subcutaneous doses of MEDI-528, a humanized anti-interleukin-9 monoclonal antibody, in two randomized phase 2a studies in subjects with asthma. BMC Pulm Med. 2011; 11:14. PMC: 3058114. DOI: 10.1186/1471-2466-11-14. View

Erpenbeck V, Hohlfeld J, Volkmann B, Hagenberg A, Geldmacher H, Braun A . Segmental allergen challenge in patients with atopic asthma leads to increased IL-9 expression in bronchoalveolar lavage fluid lymphocytes. J Allergy Clin Immunol. 2003; 111(6):1319-27. DOI: 10.1067/mai.2003.1485. View

Fu Y, Wang J, Zhou B, Pajulas A, Gao H, Ramdas B . An IL-9-pulmonary macrophage axis defines the allergic lung inflammatory environment. Sci Immunol. 2022; 7(68):eabi9768. PMC: 8991419. DOI: 10.1126/sciimmunol.abi9768. View

Li N, Mirzakhani H, Kiefer A, Koelle J, Vuorinen T, Rauh M . drives the resolution of allergic asthma. iScience. 2021; 24(10):103163. PMC: 8511896. DOI: 10.1016/j.isci.2021.103163. View

Soroosh P, Doherty T, Duan W, Mehta A, Choi H, Adams Y . Lung-resident tissue macrophages generate Foxp3+ regulatory T cells and promote airway tolerance. J Exp Med. 2013; 210(4):775-88. PMC: 3620360. DOI: 10.1084/jem.20121849. View

Seumois G, Ramirez-Suastegui C, Schmiedel B, Liang S, Peters B, Sette A . Single-cell transcriptomic analysis of allergen-specific T cells in allergy and asthma. Sci Immunol. 2020; 5(48). PMC: 7372639. DOI: 10.1126/sciimmunol.aba6087. View

Oh C, Leigh R, McLaurin K, Kim K, Hultquist M, Molfino N . A randomized, controlled trial to evaluate the effect of an anti-interleukin-9 monoclonal antibody in adults with uncontrolled asthma. Respir Res. 2013; 14:93. PMC: 3848834. DOI: 10.1186/1465-9921-14-93. View

10.

Temann U, Geba G, Rankin J, Flavell R . Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness. J Exp Med. 1998; 188(7):1307-20. PMC: 2212487. DOI: 10.1084/jem.188.7.1307. View