Early Life Microbial Exposures Shape the Crassostrea Gigas Immune System for Lifelong and Intergenerational Disease Protection

Overview

Journal Microbiome

Publisher Biomed Central

Specialties Genetics
Microbiology

Date 2022 Jun 6

PMID 35659369

Authors

Manon Fallet

Caroline Montagnani

Bruno Petton

Luc Dantan

Julien de Lorgeril

Sebastien Comarmond

Cristian Chaparro

Eve Toulza

Simon Boitard

Jean-Michel Escoubas

Agnes Vergnes

Jacqueline Le Grand

Ingo Bulla

Yannick Gueguen

Jeremie Vidal-Dupiol

Christoph Grunau

Guillaume Mitta

Celine Cosseau

Affiliations

Soon will be listed here.

Abstract

Background: The interaction of organisms with their surrounding microbial communities influences many biological processes, a notable example of which is the shaping of the immune system in early life. In the Pacific oyster, Crassostrea gigas, the role of the environmental microbial community on immune system maturation - and, importantly, protection from infectious disease - is still an open question.

Results: Here, we demonstrate that early life microbial exposure durably improves oyster survival when challenged with the pathogen causing Pacific oyster mortality syndrome (POMS), both in the exposed generation and in the subsequent one. Combining microbiota, transcriptomic, genetic, and epigenetic analyses, we show that the microbial exposure induced changes in epigenetic marks and a reprogramming of immune gene expression leading to long-term and intergenerational immune protection against POMS.

Conclusions: We anticipate that this protection likely extends to additional pathogens and may prove to be an important new strategy for safeguarding oyster aquaculture efforts from infectious disease. tag the videobyte/videoabstract in this section Video Abstract.

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