LECT2: A Pleiotropic and Promising Hepatokine, from Bench to Bedside

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2022 Jun 3

PMID 35656863

Authors

Yuan Xie

Kai-Wei Fan

Shi-Xing Guan

Yang Hu

Yi Gao

Wei-Jie Zhou

Affiliations

Soon will be listed here.

Abstract

LECT2 (leucocyte cell-derived chemotaxin 2) is a 16-kDa protein mainly produced by hepatocytes. It was first isolated in PHA-activated human T-cell leukaemia SKW-3 cells and originally identified as a novel neutrophil chemotactic factor. However, many lines of studies suggested that LECT2 was a pleiotropic protein, it not only functioned as a cytokine to exhibit chemotactic property, but also played multifunctional roles in some physiological conditions and pathological abnormalities, involving liver regeneration, neuronal development, HSC(haematopoietic stem cells) homeostasis, liver injury, liver fibrosis, hepatocellular carcinoma, metabolic disorders, inflammatory arthritides, systemic sepsis and systemic amyloidosis. Among the above studies, it was discovered that LECT2 could be a promising molecular biomarker and therapeutic target. This review summarizes LECT2-related receptors and pathways, basic and clinical researches, primarily in mice and human, for a better comprehension and management of these diseases in the future.

Citing Articles

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Global research trends and hotspots for leukocyte cell-derived chemotaxin-2 from the past to 2023: a combined bibliometric review.

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Elevated serum levels of leukocyte cell-derived chemotaxin 2 are associated with the prevalence of metabolic syndrome.

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Interorgan communication with the liver: novel mechanisms and therapeutic targets.

Zhao J, Zhang X, Li Y, Yu J, Chen Z, Niu Y Front Immunol. 2023; 14:1314123.

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