A Cross-Sectional Study of the Distribution Patterns and Potential Determinants in Plasma Selenium Status Among Chinese Adults With Hypertension

Overview

Journal Front Nutr

Specialty Nutritional Sciences

Date 2022 Jun 3

PMID 35656161

Authors

Zhuo Wang

Tengfei Lin

Yaping Wei

Yun Song

Lishun Liu

Ziyi Zhou

Xiao Huang

Ping Chen

Chengzhang Liu

Youbao Li

Binyan Wang

Jianping Li

Yan Zhang

Yong Huo

Hao Zhang

Xiping Xu

Xianhui Qin

Huiyuan Guo

Affiliations

Soon will be listed here.

Abstract

Selenium (Se) is an essential trace element in selenoproteins biosynthesis for the human body and plays an important role in the prevention and control of subsequent cardiovascular disease in adults with hypertension. However, reports on Se status and its potential determinants in populations from different regions of China are limited, especially data on adults with hypertension, a high-risk group more vulnerable to oxidative stress. Thus, we conducted a cross-sectional study from February 2017 to May 2018 of 2,599 participants (1,389 men and 1,210 women) on middle-aged to elderly adults with hypertension with a mean age of 63.1 years (SD 13.3) from 14 provinces of China and aimed to examine the relationship of plasma Se status with demographic characteristics and lifestyles. Overall, the male participants (mean value 75.0 μg/L) tended to have higher plasma Se concentrations than the female participants (73.7 μg/L) when controlling for relevant factors. There were significant differences among regions, and in age and body mass index (BMI) in plasma Se distribution, and plasma Se concentrations were significantly lower among those in the regions with relatively lower Se, aged 60 years or older, and with BMI lower than 28 kg/m. Moreover, a higher frequency of meat consumption (1-2 or ≥3 times/week vs. <1 time/week) was significantly associated with higher plasma Se concentrations in men and women, and male alcohol drinkers had significantly higher plasma Se concentrations than non-alcohol drinkers. Adequate consumption of fruits and vegetables (0.5-1.5 kg/week) was associated with higher plasma Se concentrations among women, but was associated with relatively lower plasma Se concentrations in men. Our results indicated relatively low plasma Se status in Chinese adults with hypertension from 14 provinces, while specific factors including geographic, demographic, and lifestyle characteristics and blood pressure were significantly associated with plasma Se status in this hypertensive population. In addition, more studies are required to further evaluate dietary structure and other lifestyle factors that influence circulating Se status.

Citing Articles

Selenium deficiency causes hypertension by increasing renal AT receptor expression via GPx1/HO/NF-κB pathway.

Lei L, Zhang F, Huang J, Yang X, Zhou X, Yan H Free Radic Biol Med. 2023; 200:59-72.

PMID: 36868433 PMC: 10164092. DOI: 10.1016/j.freeradbiomed.2023.02.021.

References

Li Q, Liu M, Hou J, Jiang C, Li S, Wang T . The prevalence of Keshan disease in China. Int J Cardiol. 2012; 168(2):1121-6. DOI: 10.1016/j.ijcard.2012.11.046. View

Salonen J, Salonen R, Ihanainen M, Parviainen M, Seppanen R, Kantola M . Blood pressure, dietary fats, and antioxidants. Am J Clin Nutr. 1988; 48(5):1226-32. DOI: 10.1093/ajcn/48.5.1226. View

Shetty S, Marsicano J, Copeland P . Uptake and Utilization of Selenium from Selenoprotein P. Biol Trace Elem Res. 2017; 181(1):54-61. PMC: 5680150. DOI: 10.1007/s12011-017-1044-9. View

Liu Z, Zhao L, Man Q, Wang J, Zhao W, Zhang J . Dietary Micronutrients Intake Status among Chinese Elderly People Living at Home: Data from CNNHS 2010-2012. Nutrients. 2019; 11(8). PMC: 6722721. DOI: 10.3390/nu11081787. View

Sinha N, Dabla P . Oxidative stress and antioxidants in hypertension-a current review. Curr Hypertens Rev. 2015; 11(2):132-42. DOI: 10.2174/1573402111666150529130922. View

Su L, Jin Y, Unverzagt F, Cheng Y, Hake A, Ran L . Nail Selenium Level and Diabetes in Older People in Rural China. Biomed Environ Sci. 2016; 29(11):818-824. DOI: 10.3967/bes2016.109. View

Vinceti M, Filippini T, Jablonska E, Saito Y, Wise L . Safety of selenium exposure and limitations of selenoprotein maximization: Molecular and epidemiologic perspectives. Environ Res. 2022; 211:113092. DOI: 10.1016/j.envres.2022.113092. View

Filippini T, Michalke B, Wise L, Malagoli C, Malavolti M, Vescovi L . Diet composition and serum levels of selenium species: A cross-sectional study. Food Chem Toxicol. 2018; 115:482-490. DOI: 10.1016/j.fct.2018.03.048. View

Bodnar M, Szczyglowska M, Konieczka P, Namiesnik J . Methods of Selenium Supplementation: Bioavailability and Determination of Selenium Compounds. Crit Rev Food Sci Nutr. 2014; 56(1):36-55. DOI: 10.1080/10408398.2012.709550. View

10.

Liu P, Yuan G, Zhou Q, Liu Y, He X, Zhang H . The association between metal exposure and semen quality in Chinese males: The mediating effect of androgens. Environ Pollut. 2020; 264:113975. DOI: 10.1016/j.envpol.2020.113975. View

11.

Dinh Q, Cui Z, Huang J, Tran T, Wang D, Yang W . Selenium distribution in the Chinese environment and its relationship with human health: A review. Environ Int. 2018; 112:294-309. DOI: 10.1016/j.envint.2017.12.035. View

12.

Mirnamniha M, Faroughi F, Tahmasbpour E, Ebrahimi P, Beigi Harchegani A . An overview on role of some trace elements in human reproductive health, sperm function and fertilization process. Rev Environ Health. 2019; 34(4):339-348. DOI: 10.1515/reveh-2019-0008. View

13.

Breslow R, Chen C, Graubard B, Jacobovits T, Kant A . Diets of drinkers on drinking and nondrinking days: NHANES 2003-2008. Am J Clin Nutr. 2013; 97(5):1068-75. PMC: 3625244. DOI: 10.3945/ajcn.112.050161. View

14.

Yu D, Liang D, Lei L, Zhang R, Sun X, Lin Z . Selenium geochemical distribution in the environment and predicted human daily dietary intake in northeastern Qinghai, China. Environ Sci Pollut Res Int. 2015; 22(15):11224-35. DOI: 10.1007/s11356-015-4310-4. View

15.

Vinceti M, Chawla R, Filippini T, Dutt C, Cilloni S, Loomba R . Blood pressure levels and hypertension prevalence in a high selenium environment: results from a cross-sectional study. Nutr Metab Cardiovasc Dis. 2019; 29(4):398-408. DOI: 10.1016/j.numecd.2019.01.004. View

16.

Combs Jr G . Biomarkers of selenium status. Nutrients. 2015; 7(4):2209-36. PMC: 4425141. DOI: 10.3390/nu7042209. View

17.

Wu W, Jiang S, Zhao Q, Zhang K, Wei X, Zhou T . Environmental exposure to metals and the risk of hypertension: A cross-sectional study in China. Environ Pollut. 2017; 233:670-678. DOI: 10.1016/j.envpol.2017.10.111. View

18.

Wang J, Yang L, Li H, Li Y, Wei B . Dietary selenium intake based on the Chinese Food Pagoda: the influence of dietary patterns on selenium intake. Nutr J. 2018; 17(1):50. PMC: 5941689. DOI: 10.1186/s12937-018-0358-6. View

19.

Combs Jr G . Selenium in global food systems. Br J Nutr. 2001; 85(5):517-47. DOI: 10.1079/bjn2000280. View

20.

Wang Z, Ma H, Song Y, Lin T, Liu L, Zhou Z . Plasma selenium and the risk of first stroke in adults with hypertension: a secondary analysis of the China Stroke Primary Prevention Trial. Am J Clin Nutr. 2021; 115(1):222-231. DOI: 10.1093/ajcn/nqab320. View