Impaired Procedural Memory in Narcolepsy Type 1

Overview

Journal Acta Neurol Scand

Specialty Neurology

Date 2022 Jun 2

PMID 35652281

Authors

Amanda Asp

Frida Lund

Christian Benedict

Pontus Wasling

Affiliations

Soon will be listed here.

Abstract

Objectives: Sleep enhances the consolidation of memories. Here, we investigated whether sleep-dependent memory consolidation differs between healthy subjects and narcolepsy type 1 (NT1) patients.

Material And Methods: We recruited 18 patients with NT1 and 24 healthy controls. The consolidation of spatial (declarative memory; 2-dimensional object location) and procedural (non-declarative memory; finger sequence tapping) memories was examined across one night of at-home sleep. Sleep was measured by an ambulatory sleep recording device.

Results: The overnight gain in the number of correctly recalled sequences in the finger-tapping test was smaller for NT1 patients than healthy subjects (+8.1% vs. +23.8% from pre-sleep learning to post-sleep recall, p = .035). No significant group differences were found for the overnight consolidation of spatial memory. Compared to healthy subjects, the sleep of NT1 patients was significantly more fragmented and shallow. However, no significant correlations were found between sleep parameters and overnight performance changes on the memory tests in the whole group.

Conclusion: The sleep-dependent consolidation of procedural but not spatial memories may be impaired among patients with NT1. Therefore, future studies are warranted to examine whether sleep improvement, for example, using sodium oxybate, can aid the sleep-dependent formation of procedural memories among NT1 patients.

Citing Articles

Sleep Stage Transitions and Sleep-Dependent Memory Consolidation in Children with Narcolepsy-Cataplexy.

Gagnon K, Rey A, Guignard-Perret A, Guyon A, Reynaud E, Herbillon V Children (Basel). 2023; 10(10).

PMID: 37892365 PMC: 10605014. DOI: 10.3390/children10101702.

Impaired procedural memory in narcolepsy type 1.

Asp A, Lund F, Benedict C, Wasling P Acta Neurol Scand. 2022; 146(2):186-193.

PMID: 35652281 PMC: 9544773. DOI: 10.1111/ane.13651.

References

Mukai J, Uchida S, Miyazaki S, Nishihara K, Honda Y . Spectral analysis of all-night human sleep EEG in narcoleptic patients and normal subjects. J Sleep Res. 2003; 12(1):63-71. DOI: 10.1046/j.1365-2869.2003.00331.x. View

Arnal P, Thorey V, Debellemaniere E, Ballard M, Bou Hernandez A, Guillot A . The Dreem Headband compared to polysomnography for electroencephalographic signal acquisition and sleep staging. Sleep. 2020; 43(11). PMC: 7751170. DOI: 10.1093/sleep/zsaa097. View

Mitterling T, Hogl B, Schonwald S, Hackner H, Gabelia D, Biermayr M . Sleep and Respiration in 100 Healthy Caucasian Sleepers--A Polysomnographic Study According to American Academy of Sleep Medicine Standards. Sleep. 2014; 38(6):867-75. PMC: 4434553. DOI: 10.5665/sleep.4730. View

Mazzetti M, Plazzi G, Campi C, Cicchella A, Mattarozzi K, Tuozzi G . Sleep-dependent consolidation of motor skills in patients with narcolepsy-cataplexy. Arch Ital Biol. 2012; 150(2-3):185-93. DOI: 10.4449/aib.v150i2/3.1412. View

Zigmond A, SNAITH R . The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983; 67(6):361-70. DOI: 10.1111/j.1600-0447.1983.tb09716.x. View

Sirota A, Csicsvari J, Buhl D, Buzsaki G . Communication between neocortex and hippocampus during sleep in rodents. Proc Natl Acad Sci U S A. 2003; 100(4):2065-9. PMC: 149959. DOI: 10.1073/pnas.0437938100. View

Rogers A, Aldrich M, Caruso C . Patterns of sleep and wakefulness in treated narcoleptic subjects. Sleep. 1994; 17(7):590-7. DOI: 10.1093/sleep/17.7.590. View

Ferri R, Miano S, Bruni O, Vankova J, Nevsimalova S, Vandi S . NREM sleep alterations in narcolepsy/cataplexy. Clin Neurophysiol. 2005; 116(11):2675-84. DOI: 10.1016/j.clinph.2005.08.004. View

Johns M . A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991; 14(6):540-5. DOI: 10.1093/sleep/14.6.540. View

10.

Rangtell F, Karamchedu S, Andersson P, van Egmond L, Hultgren T, Broman J . Learning performance is linked to procedural memory consolidation across both sleep and wakefulness. Sci Rep. 2017; 7(1):10234. PMC: 5579258. DOI: 10.1038/s41598-017-09263-5. View

11.

Cedernaes J, Rangtell F, Axelsson E, Yeganeh A, Vogel H, Broman J . Short Sleep Makes Declarative Memories Vulnerable to Stress in Humans. Sleep. 2015; 38(12):1861-8. PMC: 4667381. DOI: 10.5665/sleep.5228. View

12.

Cohen A, Mandrekar J, St Louis E, Silber M, Kotagal S . Comorbidities in a community sample of narcolepsy. Sleep Med. 2018; 43:14-18. PMC: 5931205. DOI: 10.1016/j.sleep.2017.11.1125. View

13.

Hertenstein E, Gabryelska A, Spiegelhalder K, Nissen C, Johann A, Umarova R . Reference Data for Polysomnography-Measured and Subjective Sleep in Healthy Adults. J Clin Sleep Med. 2018; 14(4):523-532. PMC: 5886429. DOI: 10.5664/jcsm.7036. View

14.

Asp A, Lund F, Benedict C, Wasling P . Impaired procedural memory in narcolepsy type 1. Acta Neurol Scand. 2022; 146(2):186-193. PMC: 9544773. DOI: 10.1111/ane.13651. View

15.

Nissen C, Kloepfer C, Nofzinger E, Feige B, Voderholzer U, Riemann D . Impaired sleep-related memory consolidation in primary insomnia--a pilot study. Sleep. 2006; 29(8):1068-73. DOI: 10.1093/sleep/29.8.1068. View

16.

Stepan M, Fenn K, Altmann E . Effects of sleep deprivation on procedural errors. J Exp Psychol Gen. 2018; 148(10):1828-1833. DOI: 10.1037/xge0000495. View

17.

Bixler E, Kales A, Vela-Bueno A, Drozdiak R, Jacoby J, Manfredi R . Narcolepsy/cataplexy. III: Nocturnal sleep and wakefulness patterns. Int J Neurosci. 1986; 29(3-4):305-16. DOI: 10.3109/00207458608986159. View

18.

Diekelmann S, Born J . The memory function of sleep. Nat Rev Neurosci. 2010; 11(2):114-26. DOI: 10.1038/nrn2762. View

19.

Wasling H, Bornstein A, Wasling P . Quality of life and procrastination in post-H1N1 narcolepsy, sporadic narcolepsy and idiopathic hypersomnia, a Swedish cross-sectional study. Sleep Med. 2020; 76:104-112. DOI: 10.1016/j.sleep.2020.10.014. View

20.

Graf P, Schacter D . Implicit and explicit memory for new associations in normal and amnesic subjects. J Exp Psychol Learn Mem Cogn. 1985; 11(3):501-18. DOI: 10.1037//0278-7393.11.3.501. View