Acute Effect of a Dietary Multi-Ingredient Nootropic As a Cognitive Enhancer in Young Healthy Adults: A Randomized, Triple-Blinded, Placebo-Controlled, Crossover Trial

Overview

Journal Front Nutr

Specialty Nutritional Sciences

Date 2022 May 31

PMID 35634417

Authors

Maria Medrano

Cristina Molina-Hidalgo

Juan M A Alcantara

Jonatan R Ruiz

Lucas Jurado-Fasoli

Affiliations

Soon will be listed here.

Abstract

Aim: To study the acute effect of a dietary multi-ingredient nootropic on cognitive performance in young healthy adults. We also analyzed the influence of the dietary multi-ingredient nootropic on emotional state, heart rate (HR), and heart rate variability (HRV).

Methods: This is a randomized, triple-blinded, placebo-controlled, crossover trial. In total, 26 young healthy adults (50% women; 24.9 ± 3.3 years old) ingested 10 g of a dietary multi-ingredient nootropic [Evo-Gamers; Harrison Sport Nutrition (HSN), Granada, Spain] or placebo (maltodextrin) in a randomized order (clinicaltrials.gov No. NCT04790188). After 30 min of the ingestion, participants performed a battery of cognitive performance tests to measure the processing speed, inhibitory control, working memory, cognitive flexibility, creativity, and verbal fluency. The emotional status was assessed through questionnaires, and HR and HRV were measured using a heart rate monitor.

Results: In comparison with placebo, the acute ingestion of the nootropic showed a significantly better response time in several cognitive tests (i.e., processing speed, inhibitory control, spatial working memory, and cognitive flexibility, all < 0.05 and effect size range of 0.4-0.6). It also displayed a higher accuracy in the processing speed, the inhibitory control, and cognitive flexibility tests (all < 0.05; effect size ranged from 0.4 to 0.6). Furthermore, the nootropic showed a higher creativity and positive emotions and lower sadness-depression emotions, whereas HR and HRV remained similar between placebo vs. nootropic conditions. However, there were no differences between the nootropic and placebo in verbal fluency, motivation, or anxiety (all > 0.05).

Conclusion: An acute ingestion of a dietary multi-ingredient nootropic enhances cognitive performance in comparison with placebo without negatively influencing HR or HRV in young healthy adults.

Citing Articles

Acute, dose-response effects of guayusa leaf extract on mood, cognitive and motor-cognitive performance, and blood pressure, heart rate, and ventricular repolarization.

Helwig N, Schwager L, Berry A, Zucker A, Venenga J, Sterbenz S J Int Soc Sports Nutr. 2024; 21(1):2379424.

PMID: 39014963 PMC: 11257001. DOI: 10.1080/15502783.2024.2379424.

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