Effects of Lysine-Lysine Dipeptide on Serum Amino Acid Profiles, Intestinal Morphology, and Microbiome in Suckling Piglets

Overview

Journal Front Nutr

Specialty Nutritional Sciences

Date 2022 May 31

PMID 35634396

Authors

Yuankun Deng

Hui Han

Liuqin He

Dun Deng

Jing Wang

Yulong Yin

Tiejun Li

Affiliations

Soon will be listed here.

Abstract

Aims: Small peptides are more energy-saving and efficiently absorbed compared to amino acids. Our study aimed to evaluate the effect of the Lys-Lys dipeptide on the improvement of growth performance, amino acid metabolism, and gut development in suckling piglets.

Methods And Results: Twenty-eight newborn suckling piglets were orally administrated with 0.1%, 1%, and 5% Lys-Lys dipeptide for 21 days. Our results showed that the Lys-Lys dipeptide has no significant effect on growth performance and intestinal morphology compared with the control group. We also found that the 1% Lys-Lys dipeptide significantly increased the concentrations of serum Lys, Thr, Phe, and Pro while decreasing Cys compared to the control group. Similarly, the 5% Lys-Lys dipeptide markedly increased the concentrations of serum Lys, Iso, Thr, Asp, Glu, and Pro compared to the control group. Moreover, the Lys-Lys dipeptide downregulated the expression of jejunal , and and ileal . Additionally, the Lys-Lys dipeptide decreased the microbiota richness indices and relative abundance of .

Conclusion: In this study, we found that the Lys-Lys dipeptide contributes to the metabolism of amino acids but failed to affect the growth performance of piglets. Additionally, the Lys-Lys dipeptide decreased the relative abundance of . These results provide a theoretical for the future application and research of Lys-Lys dipeptide in intestinal development of suckling piglets.

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