Virulence Factors and Insights into Pathogenicity

Overview

Journal Microorganisms

Specialty Microbiology

Date 2022 May 28

PMID 35630439

Authors

Eric A Porsch

Affiliations

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Abstract

The emergence of as an important etiology of pediatric osteoarticular infections over the past three decades has led to significant research efforts focused on understanding the pathogenicity of this fastidious Gram-negative bacterium. This work has uncovered multiple virulence factors that likely play key roles in the ability of the organism to colonize the upper respiratory tract, breach the epithelial barrier, and disseminate to distal sites of infection. Herein the current body of knowledge about virulence factors is reviewed in the context of disease pathogenesis. The work summarized here has identified multiple targets for therapeutic intervention as well as potential vaccine antigens.

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