Probiotics Function in Preventing Atopic Dermatitis in Children

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 May 28

PMID 35628229

Authors

Caterina Anania

Giulia Brindisi

Ivana Martinelli

Edoardo Bonucci

Miriam DOrsi

Sara Ialongo

Anna Nyffenegger

Tonia Raso

Mattia Spatuzzo

Giovanna De Castro

Anna Maria Zicari

Carlo Carraro

Maria Grazia Piccioni

Francesca Olivero

Affiliations

Soon will be listed here.

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by relapsing eczematous injuries and severe pruritus. In the last few years, the AD prevalence has been increasing, reaching 20% in children and 10% in adults in high-income countries. Recently, the potential role of probiotics in AD prevention has generated considerable interest. As many clinical studies show, the gut microbiota is able to modulate systemic inflammatory and immune responses influencing the development of sensitization and allergy. Probiotics are used increasingly against AD. However, the molecular mechanisms underlying the probiotics mediated anti-allergic effect remain unclear and there is controversy about their efficacy. In this narrative review, we examine the actual evidence on the effect of probiotic supplementation for AD prevention in the pediatric population, discussing also the potential biological mechanisms of action in this regard.

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