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Opinion: Interpretation of the Complexity of Innate Immune Responses by Functional Genomics

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Journal Nat Rev Immunol
Date 2002 Nov 5
PMID 12415311
Citations 21
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Abstract

Understanding how the immune system is regulated and responds to pathogens will require whole-system approaches, because the study of single immunological parameters has, so far, been unable to unlock immune-system complexity. Global transcription analysis using microarray technologies provides a new approach to the description of complex biological phenomena. Here, we discuss insights into innate immunity that have been provided by genome-wide approaches and their impact on the interpretation of immune-system complexity.

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