Advances in Immune Monitoring Approaches for Sepsis-Induced Immunosuppression

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2022 May 27

PMID 35619710

Authors

Ren-Qi Yao

Chao Ren

Li-Yu Zheng

Zhao-Fan Xia

Yong-ming Yao

Affiliations

Soon will be listed here.

Abstract

Sepsis represents a life-threatening organ dysfunction due to an aberrant host response. Of note is that majority of patients have experienced a severe immune depression during and after sepsis, which is significantly correlated with the occurrence of nosocomial infection and higher risk of in-hospital death. Nevertheless, the clinical sign of sepsis-induced immune paralysis remains highly indetectable and ambiguous. Given that, specific yet robust biomarkers for monitoring the immune functional status of septic patients are of prominent significance in clinical practice. In turn, the stratification of a subgroup of septic patients with an immunosuppressive state will greatly contribute to the implementation of personalized adjuvant immunotherapy. In this review, we comprehensively summarize the mechanism of sepsis-associated immunosuppression at the cellular level and highlight the recent advances in immune monitoring approaches targeting the functional status of both innate and adaptive immune responses.

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