Association Between Pelvic Pain Bothersomeness and Pain Sensitivity: A Community-based Cross-sectional Study of Young Adult Females in the Raine Study

Overview

Journal BJOG

Specialty Gynecology & Obstetrics

Date 2022 May 21

PMID 35596698

Authors

Darren Beales

Renata Asinelli

Marit Klokset

Lindsay OKane

Tonje Urstad

Emma Wise

Juliana Zabatiero

Judith Thompson

Jennifer Pontre

Robert Waller

Affiliations

Soon will be listed here.

Abstract

Objective: Pelvic pain has been associated with augmented nociceptive processing, but large studies controlling for multiple potential confounding factors are lacking. This study investigated the association between pelvic pain bothersomeness and pain sensitivity in young adult women, accounting for potential confounding factors.

Design: Cross-sectional study.

Setting: Community-dwelling sample.

Population: The Raine Study Gen2-22 year follow-up (n = 475).

Main Outcome Measures: The experience of bothersomeness related to pelvic pain was determined from a question in the Urogenital Distress Inventory short form. Pain sensitivity was measured using pressure pain and cold pain thresholds. Potential confounding factors included ethnicity, marital status, highest level of education, income, waist-hip ratio, level of activity, sleep quality, smoking, comorbidity history, C-reactive protein level, musculoskeletal pain experience and psychological distress.

Results: Three hundred and sixty-two women (76.2%) reported no pelvic pain bothersomeness, 74 (15.6%) reported mild pelvic pain bothersomeness and 39 (8.2%) reported moderate-severe pelvic pain bothersomeness. After adjusting for marital status (and test site), moderate-severe pelvic pain bothersomeness was associated with a lower pressure pain threshold (i.e. greater pressure pain sensitivity) (coefficient -51.46, 95% CI -98.06 to -4.86, p = 0.030). After adjusting for smoking, moderate-severe pelvic pain bothersomeness was also associated with a higher cold pain threshold (i.e. greater cold pain sensitivity) (coefficient 4.35, 95% CI 0.90-7.79, p = 0.014).

Conclusions: This study suggests augmented nociceptive processing as a contributing factor in pelvic pain bothersomeness for some women. Thorough assessment of women who present clinically with pelvic pain should consider pain sensitivity as a potential contributing factor to their presentation.

Citing Articles

Association between pelvic pain bothersomeness and pain sensitivity: A community-based cross-sectional study of young adult females in the Raine Study.

Beales D, Asinelli R, Klokset M, OKane L, Urstad T, Wise E BJOG. 2022; 129(12):1981-1991.

PMID: 35596698 PMC: 9796573. DOI: 10.1111/1471-0528.17232.

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