Exosomal MiRNAs in Osteosarcoma: Biogenesis and Biological Functions

Overview

Journal Front Pharmacol

Date 2022 May 20

PMID 35592419

Authors

Jinxin Tang

Jieyu He

Chengyao Feng

Chao Tu

Affiliations

Soon will be listed here.

Abstract

MiRNAs are a group of non-coding RNA molecules that function in mRNA translational inhibition base-pairing with complementary sequences in target mRNA. In oncology, miRNAs have raised great attention due to their aberrant expression and pivotal roles in the pathogenesis of multiple malignancies including osteosarcoma. MiRNAs can be transported by exosome, the nano-extracellular vesicle with a diameter of 30-150 nm. Recently, a growing number of studies have demonstrated that exosomal miRNAs play a critical role in tumor initiation and progression, by exerting multiple biological functions including metastasis, angiogenesis, drug resistance and immunosuppression. In this review, we aim to depict the biogenesis of exosomal miRNAs and summarize the potential diagnostic and therapeutic functions of exosomal miRNAs in osteosarcoma.

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References

Wei D, Zhan W, Gao Y, Huang L, Gong R, Wang W . RAB31 marks and controls an ESCRT-independent exosome pathway. Cell Res. 2020; 31(2):157-177. PMC: 8027411. DOI: 10.1038/s41422-020-00409-1. View

Zhou J, Deng S, Fang H, Yu G, Peng H . Hsa-let-7g promotes osteosarcoma by reducing HOXB1 to activate NF-kB pathway. Biomed Pharmacother. 2018; 109:2335-2341. DOI: 10.1016/j.biopha.2018.11.026. View

Kallen M, Hornick J . The 2020 WHO Classification: What's New in Soft Tissue Tumor Pathology?. Am J Surg Pathol. 2020; 45(1):e1-e23. DOI: 10.1097/PAS.0000000000001552. View

Xu G, Zhang B, Ye J, Cao S, Shi J, Zhao Y . Exosomal miRNA-139 in cancer-associated fibroblasts inhibits gastric cancer progression by repressing MMP11 expression. Int J Biol Sci. 2019; 15(11):2320-2329. PMC: 6775321. DOI: 10.7150/ijbs.33750. View

Lin Q, Zhou C, Bai M, Zhu D, Chen J, Wang H . Exosome-mediated miRNA delivery promotes liver cancer EMT and metastasis. Am J Transl Res. 2020; 12(3):1080-1095. PMC: 7137059. View

Qin F, Tang H, Zhang Y, Zhang Z, Huang P, Zhu J . Bone marrow-derived mesenchymal stem cell-derived exosomal microRNA-208a promotes osteosarcoma cell proliferation, migration, and invasion. J Cell Physiol. 2019; 235(5):4734-4745. DOI: 10.1002/jcp.29351. View

Thakur A, Xu C, Li W, Qiu G, He B, Ng S . In vivo liquid biopsy for glioblastoma malignancy by the AFM and LSPR based sensing of exosomal CD44 and CD133 in a mouse model. Biosens Bioelectron. 2021; 191:113476. DOI: 10.1016/j.bios.2021.113476. View

Santangelo L, Giurato G, Cicchini C, Montaldo C, Mancone C, Tarallo R . The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting. Cell Rep. 2016; 17(3):799-808. DOI: 10.1016/j.celrep.2016.09.031. View

Han M, Hu J, Lu P, Cao H, Yu C, Li X . Exosome-transmitted miR-567 reverses trastuzumab resistance by inhibiting ATG5 in breast cancer. Cell Death Dis. 2020; 11(1):43. PMC: 6976584. DOI: 10.1038/s41419-020-2250-5. View

10.

Shi Y, Liu Z, Lin Q, Luo Q, Cen Y, Li J . MiRNAs and Cancer: Key Link in Diagnosis and Therapy. Genes (Basel). 2021; 12(8). PMC: 8395027. DOI: 10.3390/genes12081289. View

11.

Lu S, Liao Q, Tang L . MiR-155 affects osteosarcoma cell proliferation and invasion through regulating NF-κB signaling pathway. Eur Rev Med Pharmacol Sci. 2018; 22(22):7633-7639. DOI: 10.26355/eurrev_201811_16380. View

12.

Yang R, Wang D, Han S, Gu Y, Li Z, Deng L . MiR-206 suppresses the deterioration of intrahepatic cholangiocarcinoma and promotes sensitivity to chemotherapy by inhibiting interactions with stromal CAFs. Int J Biol Sci. 2022; 18(1):43-64. PMC: 8692143. DOI: 10.7150/ijbs.62602. View

13.

He Q, Ye A, Ye W, Liao X, Qin G, Xu Y . Cancer-secreted exosomal miR-21-5p induces angiogenesis and vascular permeability by targeting KRIT1. Cell Death Dis. 2021; 12(6):576. PMC: 8178321. DOI: 10.1038/s41419-021-03803-8. View

14.

Vietri M, Radulovic M, Stenmark H . The many functions of ESCRTs. Nat Rev Mol Cell Biol. 2019; 21(1):25-42. DOI: 10.1038/s41580-019-0177-4. View

15.

Wei F, Ma C, Zhou T, Dong X, Luo Q, Geng L . Exosomes derived from gemcitabine-resistant cells transfer malignant phenotypic traits via delivery of miRNA-222-3p. Mol Cancer. 2017; 16(1):132. PMC: 5526308. DOI: 10.1186/s12943-017-0694-8. View

16.

Li Y, Tao Y, Gao S, Li P, Zheng J, Zhang S . Cancer-associated fibroblasts contribute to oral cancer cells proliferation and metastasis via exosome-mediated paracrine miR-34a-5p. EBioMedicine. 2018; 36:209-220. PMC: 6197737. DOI: 10.1016/j.ebiom.2018.09.006. View

17.

Zhang H, Deng T, Liu R, Ning T, Yang H, Liu D . CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer. Mol Cancer. 2020; 19(1):43. PMC: 7045485. DOI: 10.1186/s12943-020-01168-8. View

18.

Galardi A, Colletti M, Di Paolo V, Vitullo P, Antonetti L, Russo I . Exosomal MiRNAs in Pediatric Cancers. Int J Mol Sci. 2019; 20(18). PMC: 6770697. DOI: 10.3390/ijms20184600. View

19.

Zhang H, Wang J, Ren T, Huang Y, Liang X, Yu Y . Bone marrow mesenchymal stem cell-derived exosomal miR-206 inhibits osteosarcoma progression by targeting TRA2B. Cancer Lett. 2020; 490:54-65. DOI: 10.1016/j.canlet.2020.07.008. View

20.

Cooks T, Pateras I, Jenkins L, Patel K, Robles A, Morris J . Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246. Nat Commun. 2018; 9(1):771. PMC: 5823939. DOI: 10.1038/s41467-018-03224-w. View