Cancer-secreted Exosomal MiR-21-5p Induces Angiogenesis and Vascular Permeability by Targeting KRIT1

Overview

Journal Cell Death Dis

Specialties Cell Biology
General Medicine

Date 2021 Jun 5

PMID 34088891

Citations 60

Authors

Qinglian He

Aihua Ye

Weibiao Ye

Xiaomin Liao

Guoqiang Qin

Yongqiang Xu

Yuting Yin

Huanqian Luo

Muhua Yi

Liying Xian

Shihao Zhang

Xiyuan Qin

Wei Zhu

Yuling Li

Affiliations

Soon will be listed here.

Abstract

Cancer-secreted exosomes are critical mediators of cancer-host crosstalk. In the present study, we showed the delivery of miR-21-5p from colorectal cancer (CRC) cells to endothelial cells via exosomes increased the amount of miR-21-5p in recipient cells. MiR-21-5p suppressed Krev interaction trapped protein 1 (KRIT1) in recipient HUVECs and subsequently activated β-catenin signaling pathway and increased their downstream targets VEGFa and Ccnd1, which consequently promoted angiogenesis and vascular permeability in CRC. A strong inverse correlation between miR-21-5p and KRIT1 expression levels was observed in CRC-adjacent vessels. Furthermore, miR-21-5p expression in circulating exosomes was markedly higher in CRC patients than in healthy donors. Thus, our data suggest that exosomal miR-21-5p is involved in angiogenesis and vascular permeability in CRC and may be used as a potential new therapeutic target.

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