Clinical Impact of Computational Heart Valve Models

Overview

Journal Materials (Basel)

Publisher MDPI

Date 2022 May 20

PMID 35591636

Authors

Milan Toma

Shelly Singh-Gryzbon

Elisabeth Frankini

Zhenglun Alan Wei

Ajit P Yoganathan

Affiliations

Soon will be listed here.

Abstract

This paper provides a review of engineering applications and computational methods used to analyze the dynamics of heart valve closures in healthy and diseased states. Computational methods are a cost-effective tool that can be used to evaluate the flow parameters of heart valves. Valve repair and replacement have long-term stability and biocompatibility issues, highlighting the need for a more robust method for resolving valvular disease. For example, while fluid-structure interaction analyses are still scarcely utilized to study aortic valves, computational fluid dynamics is used to assess the effect of different aortic valve morphologies on velocity profiles, flow patterns, helicity, wall shear stress, and oscillatory shear index in the thoracic aorta. It has been analyzed that computational flow dynamic analyses can be integrated with other methods to create a superior, more compatible method of understanding risk and compatibility.

Citing Articles

A chronological history of heart valve prostheses to offer perspectives of their limitations.

Evangelista R, Pires A, Nogueira B Front Bioeng Biotechnol. 2025; 13:1533421.

PMID: 40028289 PMC: 11868121. DOI: 10.3389/fbioe.2025.1533421.

Computational modelling of valvular heart disease: haemodynamic insights and clinical implications.

Seman M, Stephens A, Kaye D, Gregory S, Stub D Front Bioeng Biotechnol. 2024; 12:1462542.

PMID: 39600889 PMC: 11588460. DOI: 10.3389/fbioe.2024.1462542.

Analysis of Umbilical Artery Hemodynamics in Development of Intrauterine Growth Restriction Using Computational Fluid Dynamics with Doppler Ultrasound.

Song X, Wang J, Sun K, Lee C Bioengineering (Basel). 2024; 11(11).

PMID: 39593828 PMC: 11591627. DOI: 10.3390/bioengineering11111169.

Transformative Potential of AI in Healthcare: Definitions, Applications, and Navigating the Ethical Landscape and Public Perspectives.

Bekbolatova M, Mayer J, Ong C, Toma M Healthcare (Basel). 2024; 12(2).

PMID: 38255014 PMC: 10815906. DOI: 10.3390/healthcare12020125.

Modeling Dynamics of the Cardiovascular System Using Fluid-Structure Interaction Methods.

Syed F, Khan S, Toma M Biology (Basel). 2023; 12(7).

PMID: 37508455 PMC: 10376821. DOI: 10.3390/biology12071026.

References

Bryant M, Jones R, Langley S, Livesey S, Monro J . Degenerative mitral regurgitation: when should we operate?. Ann Thorac Surg. 1999; 66(5):1579-84. DOI: 10.1016/s0003-4975(98)00947-3. View

Veerappan M, Cheekoty P, Sazzad F, Kofidis T . Mitral valve re-repair vs replacement following failed initial repair: a systematic review and meta-analysis. J Cardiothorac Surg. 2020; 15(1):304. PMC: 7542900. DOI: 10.1186/s13019-020-01344-3. View

Xu F, Johnson E, Wang C, Jafari A, Yang C, Sacks M . Computational investigation of left ventricular hemodynamics following bioprosthetic aortic and mitral valve replacement. Mech Res Commun. 2021; 112. PMC: 8301225. DOI: 10.1016/j.mechrescom.2020.103604. View

Tiwary B . Computational medicine: quantitative modeling of complex diseases. Brief Bioinform. 2019; 21(2):429-440. DOI: 10.1093/bib/bbz005. View

He S, Weston M, Lemmon J, Jensen M, Levine R, Yoganathan A . Geometric distribution of chordae tendineae: an important anatomic feature in mitral valve function. J Heart Valve Dis. 2000; 9(4):495-501; discussion 502-3. View

Toma M, Bloodworth 4th C, Einstein D, Pierce E, Cochran R, Yoganathan A . High-resolution subject-specific mitral valve imaging and modeling: experimental and computational methods. Biomech Model Mechanobiol. 2016; 15(6):1619-1630. DOI: 10.1007/s10237-016-0786-1. View

Caballero A, Mao W, McKay R, Hahn R, Sun W . A Comprehensive Engineering Analysis of Left Heart Dynamics After MitraClip in a Functional Mitral Regurgitation Patient. Front Physiol. 2020; 11:432. PMC: 7221026. DOI: 10.3389/fphys.2020.00432. View

Yousefnia M, Dehestani A, Saidi B, Roshanali F, Mandegar M, Alaeddini F . Papillary muscle repositioning in valve replacement for left ventricular dysfunction: ischemic mitral regurgitation. Ann Thorac Surg. 2010; 90(2):497-502. DOI: 10.1016/j.athoracsur.2010.04.060. View

Jamari J, Ammarullah M, Md Saad A, Syahrom A, Uddin M, van der Heide E . The Effect of Bottom Profile Dimples on the Femoral Head on Wear in Metal-on-Metal Total Hip Arthroplasty. J Funct Biomater. 2021; 12(2). PMC: 8293231. DOI: 10.3390/jfb12020038. View

10.

Winston T, Suddhapas K, Wang C, Ramos R, Soman P, Ma Z . Serum-Free Manufacturing of Mesenchymal Stem Cell Tissue Rings Using Human-Induced Pluripotent Stem Cells. Stem Cells Int. 2019; 2019:5654324. PMC: 6350554. DOI: 10.1155/2019/5654324. View

11.

Savarese G, Lund L . Global Public Health Burden of Heart Failure. Card Fail Rev. 2017; 3(1):7-11. PMC: 5494150. DOI: 10.15420/cfr.2016:25:2. View

12.

Bavo A, Pouch A, Degroote J, Vierendeels J, Gorman J, Gorman R . Patient-specific CFD models for intraventricular flow analysis from 3D ultrasound imaging: Comparison of three clinical cases. J Biomech. 2016; 50:144-150. PMC: 5191945. DOI: 10.1016/j.jbiomech.2016.11.039. View

13.

Bortolotti U, Celiento M, Pratali S, Anastasio G, Pucci A . Recurrent mitral regurgitation due to ruptured artificial chordae: case report and review of the literature. J Heart Valve Dis. 2012; 21(4):440-3. View

14.

Atkins S, McNally A, Sucosky P . Mechanobiology in Cardiovascular Disease Management: Potential Strategies and Current Needs. Front Bioeng Biotechnol. 2016; 4:79. PMC: 5056184. DOI: 10.3389/fbioe.2016.00079. View

15.

Fumagalli I, Fedele M, Vergara C, Dede L, Ippolito S, Nicolo F . An image-based computational hemodynamics study of the Systolic Anterior Motion of the mitral valve. Comput Biol Med. 2020; 123:103922. DOI: 10.1016/j.compbiomed.2020.103922. View

16.

Hetzer R, Del Maria Javier M, Wagner F, Loebe M, Delmo E . Organ-saving surgical alternatives to treatment of heart failure. Cardiovasc Diagn Ther. 2021; 11(1):213-225. PMC: 7944209. DOI: 10.21037/cdt-20-285. View

17.

Wang H, Song H, Yang Y, Wu Z, Hu R, Chen J . Hemodynamic testing using three-dimensional printing and computational fluid dynamics preoperatively may provide more information in mitral repair than traditional image dataset. Ann Transl Med. 2021; 9(8):632. PMC: 8106081. DOI: 10.21037/atm-20-7960. View

18.

Kim Y, Czer L, Soukiasian H, De Robertis M, Magliato K, Blanche C . Ischemic mitral regurgitation: revascularization alone versus revascularization and mitral valve repair. Ann Thorac Surg. 2005; 79(6):1895-901. DOI: 10.1016/j.athoracsur.2004.11.005. View

19.

Blum K, Drews J, Breuer C . Tissue-Engineered Heart Valves: A Call for Mechanistic Studies. Tissue Eng Part B Rev. 2018; 24(3):240-253. PMC: 5994154. DOI: 10.1089/ten.TEB.2017.0425. View

20.

Chung J, Im H, Kim S, Park J, Jung Y . Toward Biomimetic Scaffolds for Tissue Engineering: 3D Printing Techniques in Regenerative Medicine. Front Bioeng Biotechnol. 2020; 8:586406. PMC: 7671964. DOI: 10.3389/fbioe.2020.586406. View