Alpha 2.0
Login Register
» Articles » PMID: 3558822

Accelerated Transfer of Cholesteryl Esters in Dyslipidemic Plasma. Role of Cholesteryl Ester Transfer Protein

Overview
Journal J Clin Invest
Specialty General Medicine
Date 1987 Apr 1
PMID 3558822
Citations 24
Authors
A Tall
E Granot
R Brocia
I Tabas
C Hesler
K Williams
M Denke
Affiliations
Soon will be listed here.
Abstract

Plasma cholesteryl esters, synthesized in the high density lipoproteins (HDL), may be transferred to other lipoproteins by a cholesteryl ester transfer protein (CETP). We found a twofold increase in mass transfer of cholesteryl ester from HDL to apoB-containing lipoproteins in incubated hypercholesterolemic rabbit plasma compared with control. There was a two- to fourfold increase in the activity of CETP, measured in an isotopic assay in hypercholesterolemic plasma. A CETP-like molecule was isolated in increased amounts from hypercholesterolemic plasma. Incubated plasma from four dysbetalipoproteinemic subjects also showed an increase (threefold) in cholesteryl ester mass transfer, compared with normolipidemic controls. There was a twofold increase in the activity of CETP, assayed in whole or lipoprotein-free plasma. Thus, there is increased transfer of cholesteryl esters from HDL to potentially atherogenic apoB-containing lipoproteins in dyslipidemic rabbit and human plasma. The enhanced transfer results in part from increased activity of CETP, possibly reflecting an increase in CETP mass.

Citing Articles

Postprandial remodeling of high-density lipoprotein following high saturated fat and high carbohydrate meals.

Averill M, Rubinow K, Cain K, Wimberger J, Babenko I, Becker J J Clin Lipidol. 2019; 14(1):66-76.e11.

PMID: 31859127 PMC: 7085425. DOI: 10.1016/j.jacl.2019.11.002.

Treatment of Dyslipidemias to Prevent Cardiovascular Disease in Patients with Type 2 Diabetes.

Khavandi M, Duarte F, Ginsberg H, Reyes-Soffer G Curr Cardiol Rep. 2017; 19(1):7.

PMID: 28132397 PMC: 5503120. DOI: 10.1007/s11886-017-0818-1.

Evaluation of CETP activity in vivo under non-steady-state conditions: influence of anacetrapib on HDL-TG flux.

McLaren D, Previs S, Phair R, Stout S, Xie D, Chen Y J Lipid Res. 2015; 57(3):398-409.

PMID: 26658238 PMC: 4766989. DOI: 10.1194/jlr.M063842.

Arginine-directed glycation and decreased HDL plasma concentration and functionality.

Godfrey L, Yamada-Fowler N, Smith J, Thornalley P, Rabbani N Nutr Diabetes. 2014; 4:e134.

PMID: 25177914 PMC: 4183972. DOI: 10.1038/nutd.2014.31.

Molecular cloning of hamster lipid transfer inhibitor protein (apolipoprotein F) and regulation of its expression by hyperlipidemia.

Izem L, Morton R J Lipid Res. 2008; 50(4):676-84.

PMID: 19008550 PMC: 2656661. DOI: 10.1194/jlr.M800429-JLR200.

References
1.
Fainaru M, Mahley R, Hamilton R, Innerarity T . Structural and metabolic heterogeneity of beta-very low density lipoproteins from cholesterol-fed dogs and from humans with type III hyperlipoproteinemia. J Lipid Res. 1982; 23(5):702-14. View
2.
Reardon M, Poapst M, Steiner G . The independent synthesis of intermediate density lipoproteins in type III hyperlipoproteinemia. Metabolism. 1982; 31(5):421-7. DOI: 10.1016/0026-0495(82)90228-1. View
3.
Kane J, Chen G, Hamilton R, Hardman D, Malloy M, HAVEL R . Remnants of lipoproteins of intestinal and hepatic origin in familial dysbetalipoproteinemia. Arteriosclerosis. 1983; 3(1):47-56. DOI: 10.1161/01.atv.3.1.47. View
4.
Fielding P, Fielding C, HAVEL R, Kane J, Tun P . Cholesterol net transport, esterification, and transfer in human hyperlipidemic plasma. J Clin Invest. 1983; 71(3):449-60. PMC: 436892. DOI: 10.1172/jci110789. View
5.
Patsch J, Karlin J, Scott L, Smith L, Gotto Jr A . Inverse relationship between blood levels of high density lipoprotein subfraction 2 and magnitude of postprandial lipemia. Proc Natl Acad Sci U S A. 1983; 80(5):1449-53. PMC: 393615. DOI: 10.1073/pnas.80.5.1449. View