» Articles » PMID: 35584635

Gene Therapy for Female Infertility: A Farfetched Dream or Reality?

Overview
Journal Cell Rep Med
Publisher Cell Press
Date 2022 May 18
PMID 35584635
Authors
Affiliations
Soon will be listed here.
Abstract

A major cause of infertility in women is impaired ovulation or oogenesis. In this issue of Cell Reports Medicine, Kanatsu-Shinohara et al. demonstrate the potential of gene delivery with adeno-associated virus that can cross the blood-follicle barrier and restore oogenesis in congenitally infertile mice.

Citing Articles

Leukemic Cells Infiltrate the Ovaries Without Damaging Ovarian Reserve in an Acute Myeloid Leukemia Mouse Model.

Abazarikia A, Luan Y, So W, Becker M, Panda S, Swenson S Endocrinology. 2025; 166(4).

PMID: 39888387 PMC: 11890401. DOI: 10.1210/endocr/bqaf022.


Nanomedicine for Maternal and Fetal Health.

Carter D, Better M, Abbasi S, Zulfiqar F, Shapiro R, Ensign L Small. 2023; 20(41):e2303682.

PMID: 37817368 PMC: 11004090. DOI: 10.1002/smll.202303682.

References
1.
Rajasekaran S, Thatte J, Periasamy J, Javali A, Jayaram M, Sen D . Infectivity of adeno-associated virus serotypes in mouse testis. BMC Biotechnol. 2018; 18(1):70. PMC: 6211462. DOI: 10.1186/s12896-018-0479-1. View

2.
Watanabe S, Kanatsu-Shinohara M, Ogonuki N, Matoba S, Ogura A, Shinohara T . Adeno-associated virus-mediated delivery of genes to mouse spermatogonial stem cells. Biol Reprod. 2017; 96(1):221-231. DOI: 10.1095/biolreprod.116.143495. View

3.
Watanabe S, Kanatsu-Shinohara M, Ogonuki N, Matoba S, Ogura A, Shinohara T . In Vivo Genetic Manipulation of Spermatogonial Stem Cells and Their Microenvironment by Adeno-Associated Viruses. Stem Cell Reports. 2018; 10(5):1551-1564. PMC: 5995272. DOI: 10.1016/j.stemcr.2018.03.005. View

4.
Ikawa M, Tergaonkar V, Ogura A, Ogonuki N, Inoue K, Verma I . Restoration of spermatogenesis by lentiviral gene transfer: offspring from infertile mice. Proc Natl Acad Sci U S A. 2002; 99(11):7524-9. PMC: 124271. DOI: 10.1073/pnas.072207299. View

5.
Kanatsu-Shinohara M, Lee J, Miyazaki T, Morimoto H, Shinohara T . Adeno-associated-virus-mediated gene delivery to ovaries restores fertility in congenital infertile mice. Cell Rep Med. 2022; 3(5):100606. PMC: 9133397. DOI: 10.1016/j.xcrm.2022.100606. View