ROS-Targeted Depression Therapy Via BSA-Incubated Ceria Nanoclusters

Overview

Journal Nano Lett

Publisher American Chemical Society

Specialty Biotechnology

Date 2022 May 18

PMID 35583518

Authors

Shengyang Fu

Huili Chen

Weitao Yang

Xiaohuan Xia

Shu Zhao

Xiaonan Xu

Pu Ai

Qingyuan Cai

Xiangyu Li

Yi Wang

Jie Zhu

Bingbo Zhang

Jialin C Zheng

Affiliations

Soon will be listed here.

Abstract

Depression is one of the most fatal mental diseases, and there is currently a lack of efficient drugs for the treatment of depression. Emerging evidence has indicated oxidative stress as a key pathological feature of depression. We targeted reactive oxygen species (ROS) and synthesized CeO@BSA nanoclusters as a novel antidepression nanodrug a convenient, green, and highly effective bovine serum albumin (BSA) incubation strategy. CeO@BSA has ultrasmall size (2 nm) with outstanding ROS scavenging and blood-brain barrier crossing capacity, rapid metabolism, and negligible adverse effects and . CeO@BSA administration alleviates depressive behaviors and depression-related pathological changes of the chronic restraint stress-induced depressive model, suggesting promising therapeutic effects of CeO@BSA for the treatment of depression. Our study proved the validity by directly using nanodrugs as antidepression drugs instead of using them as a nanocarrier, which greatly expands the application of nanomaterials in depression treatment.

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