Catalytic Activity Tunable Ceria Nanoparticles Prevent Chemotherapy-induced Acute Kidney Injury Without Interference with Chemotherapeutics

Overview

Journal Nat Commun

Specialty Biology

Date 2021 Mar 5

PMID 33664241

Citations 66

Authors

Qinjie Weng

Heng Sun

Chunyan Fang

Fan Xia

Hongwei Liao

Jiyoung Lee

Jincheng Wang

An Xie

Jiafeng Ren

Xia Guo

Fangyuan Li

Bo Yang

Daishun Ling

Affiliations

Soon will be listed here.

Abstract

Acute kidney injury (AKI) is a prevalent and lethal adverse event that severely affects cancer patients receiving chemotherapy. It is correlated with the collateral damage to renal cells caused by reactive oxygen species (ROS). Currently, ROS management is a practical strategy that can reduce the risk of chemotherapy-related AKI, but at the cost of chemotherapeutic efficacy. Herein, we report catalytic activity tunable ceria nanoparticles (CNPs) that can prevent chemotherapy-induced AKI without interference with chemotherapeutic agents. Specifically, in the renal cortex, CNPs exhibit catalytic activity that decomposes hydrogen peroxide, and subsequently regulate the ROS-involved genes by activating the Nrf2/Keap1 signaling pathway. These restore the redox homeostasis for the protection of kidney tubules. Under an acidic tumor microenvironment, CNPs become inert due to the excessive H that disrupts the re-exposure of active catalytic sites, allowing a buildup of chemotherapy-mediated ROS generation to kill cancer cells. As ROS-modulating agents, CNPs incorporated with context-dependent catalytic activity, hold a great potential for clinical prevention and treatment of AKI in cancer patients.

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