Characterization of a Human Orphon 28 S Ribosomal DNA

Overview

Journal Gene

Specialty Molecular Biology

Date 1986 Jan 1

PMID 3557129

Citations 8

Authors

J Munro

R H BURDON

D P. Leader

Affiliations

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Abstract

We have isolated clones in which two regions of the human genome are represented, each containing an orphon: a dispersed copy of 28S rDNA. Nucleotide (nt) sequence analysis established that one of these, H28S-O1, corresponds to nt 3627-4105 of human 28S rDNA, but in a mutated form. The orphon was flanked on one side by a portion of the L1Hs long interspersed repeat family of the human genome. Although H25S-O1 is not flanked by the terminal direct repeats characteristic of transposed DNA, it is possible that it is a processed pseudogene.

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