Actual Associations Between HLA Haplotype and Graves' Disease Development

Overview

Journal J Clin Med

Specialty General Medicine

Date 2022 May 14

PMID 35566618

Authors

Katarzyna Zawadzka-Starczewska

Boguslaw Tymoniuk

Bartlomiej Stasiak

Andrzej Lewinski

Magdalena Stasiak

Affiliations

Soon will be listed here.

Abstract

The association between HLA and the risk of Graves' disease (GD) has been analyzed for many years. However, the results were often inconsistent and mostly regarded Asian populations. The purpose of our study was to perform HLA genotyping using a next-generation sequencing (NGS) method in Caucasians, to find out which alleles are eventually correlated with GD morbidity as well as which of them can be considered protective. were genotyped using a next-generation sequencing method in 2376 persons, including 159 GD patients and 2217 healthy controls. We have demonstrated a significant association between the risk of GD and the following alleles: . The alleles are novel GD-associated, previously not-reported independent ones with no linkage disequilibrium with other high-risk alleles. On the other hand, the frequencies of were significantly lower in GD compared to controls. This study demonstrated the actual relationships between HLA and GD based on the NGS method and provided a novel set of alleles as a reliable tool for an individual personalized risk assessment.

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