Strong Correlation Between HLA and Clinical Course of Subacute Thyroiditis-A Report of the Three Siblings

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2020 Nov 3

PMID 33138008

Citations 11

Authors

Magdalena Stasiak

Andrzej Lewinski

Affiliations

Soon will be listed here.

Abstract

Subacute thyroiditis (SAT) is a thyroid inflammatory disease with susceptibility associated with the presence of human leukocyte antigen (, , and . Previous viral infection is considered as a triggering factor in genetically predisposed individuals. The influence of HLA on the SAT course was previously suggested. We aim to present the three siblings-female twins and their brother-with very close onset but different clinical courses of SAT, which appeared to be HLA-dependent. The HLA profile in the reported three siblings is strongly correlated with both SAT and Graves' disease (GD), however the coexistence of particular sets of high risk and protective alleles seems to be crucial for the GD development and the SAT course. The co-occurrence of and/or , possibly together with the lack of and seems to be key factors protecting against the development of GD with high TRAb levels, as well as against the recurrent SAT course and steroid dependence.

Citing Articles

Diagnosis of Graves' Disease during Treatment for Subacute Thyroiditis.

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The co-occurrence of SAT, hypophysitis, and Schnitzler syndrome after COVID-19 vaccination: the first described case.

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Significance of HLA in Graves' disease and Graves' orbitopathy in Asian and Caucasian populations - a systematic review.

Stasiak M, Stasiak B, Zawadzka-Starczewska K, Lewinski A Front Immunol. 2023; 14:1256922.

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