Epidemiology, Risk Factors and Diagnosis of Small Bowel Adenocarcinoma

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2022 May 14

PMID 35565398

Authors

Thomas Aparicio

Atanas Pachev

Pierre Laurent-Puig

Magali Svrcek

Affiliations

Soon will be listed here.

Abstract

Adenocarcinomas of the small intestine are rare tumors but their incidence is increasing. There is a slight male predominance. The median age at diagnosis is the 6th decade. The most frequent primary location is the duodenum. There is no clearly identified environmental risk factor, but adenocarcinomas of the small intestine are associated in almost 20% of cases with predisposing diseases (Crohn's disease, Lynch syndrome, familial adenomatous polyposis, Peutz-Jeghers syndrome and celiac disease).

Citing Articles

Primary adenocarcinoma of the upper jejunum.

Sanada Y J Gen Fam Med. 2024; 25(5):277-279.

PMID: 39574549 PMC: 11577291. DOI: 10.1002/jgf2.695.

Bibliometrics analysis on the research status and trends of small bowel adenocarcinoma: 1923-2023.

Lu Y, Pan C, Hu X, Sun J Front Oncol. 2024; 14:1407315.

PMID: 39234397 PMC: 11371555. DOI: 10.3389/fonc.2024.1407315.

Celiac Disease Deep Learning Image Classification Using Convolutional Neural Networks.

Carreras J J Imaging. 2024; 10(8).

PMID: 39194989 PMC: 11355344. DOI: 10.3390/jimaging10080200.

Identifying risk and prognostic factors for synchronous liver metastasis in small bowel adenocarcinoma: a predictive analysis using the SEER database.

Xu D, He Y, Liao C, Tan J Front Surg. 2024; 11:1437124.

PMID: 39136035 PMC: 11317383. DOI: 10.3389/fsurg.2024.1437124.

Genomic profiling of small bowel adenocarcinoma: a pooled analysis from 3 databases.

Aparicio T, Henriques J, Svrcek M, Zaanan A, Manfredi S, Casadei-Gardini A Br J Cancer. 2024; 131(1):49-62.

PMID: 38745088 PMC: 11231144. DOI: 10.1038/s41416-024-02687-7.

References

Ushiku T, Arnason T, Fukayama M, Lauwers G . Extra-ampullary duodenal adenocarcinoma. Am J Surg Pathol. 2014; 38(11):1484-93. DOI: 10.1097/PAS.0000000000000278. View

Palascak-Juif V, Bouvier A, Cosnes J, Flourie B, Bouche O, Cadiot G . Small bowel adenocarcinoma in patients with Crohn's disease compared with small bowel adenocarcinoma de novo. Inflamm Bowel Dis. 2005; 11(9):828-32. DOI: 10.1097/01.mib.0000179211.03650.b6. View

Alvi M, McArt D, Kelly P, Fuchs M, Alderdice M, McCabe C . Comprehensive molecular pathology analysis of small bowel adenocarcinoma reveals novel targets with potential for clinical utility. Oncotarget. 2015; 6(25):20863-74. PMC: 4673235. DOI: 10.18632/oncotarget.4576. View

Locher C, Batumona B, Afchain P, Carrere N, Samalin E, Cellier C . Small bowel adenocarcinoma: French intergroup clinical practice guidelines for diagnosis, treatments and follow-up (SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO). Dig Liver Dis. 2017; 50(1):15-19. DOI: 10.1016/j.dld.2017.09.123. View

Lepage C, Bouvier A, Manfredi S, Dancourt V, Faivre J . Incidence and management of primary malignant small bowel cancers: a well-defined French population study. Am J Gastroenterol. 2006; 101(12):2826-32. DOI: 10.1111/j.1572-0241.2006.00854.x. View

Aparicio T, Svrcek M, Henriques J, Afchain P, Lievre A, Tougeron D . Panel gene profiling of small bowel adenocarcinoma: Results from the NADEGE prospective cohort. Int J Cancer. 2020; 148(7):1731-1742. DOI: 10.1002/ijc.33392. View

Perkins G, Svrcek M, Bouchet-Doumenq C, Voron T, Colussi O, Debove C . Can we classify ampullary tumours better? Clinical, pathological and molecular features. Results of an AGEO study. Br J Cancer. 2019; 120(7):697-702. PMC: 6462032. DOI: 10.1038/s41416-019-0415-8. View

Svrcek M, Jourdan F, Sebbagh N, Couvelard A, Chatelain D, Mourra N . Immunohistochemical analysis of adenocarcinoma of the small intestine: a tissue microarray study. J Clin Pathol. 2003; 56(12):898-903. PMC: 1770133. DOI: 10.1136/jcp.56.12.898. View

Adsay V, Ohike N, Tajiri T, Kim G, Krasinskas A, Balci S . Ampullary region carcinomas: definition and site specific classification with delineation of four clinicopathologically and prognostically distinct subsets in an analysis of 249 cases. Am J Surg Pathol. 2012; 36(11):1592-608. DOI: 10.1097/PAS.0b013e31826399d8. View

10.

Delaunoit T, Neczyporenko F, Limburg P, Erlichman C . Pathogenesis and risk factors of small bowel adenocarcinoma: a colorectal cancer sibling?. Am J Gastroenterol. 2005; 100(3):703-10. DOI: 10.1111/j.1572-0241.2005.40605.x. View

11.

Elriz K, Carrat F, Carbonnel F, Marthey L, Bouvier A, Beaugerie L . Incidence, presentation, and prognosis of small bowel adenocarcinoma in patients with small bowel Crohn's disease: a prospective observational study. Inflamm Bowel Dis. 2013; 19(9):1823-6. DOI: 10.1097/MIB.0b013e31828c84f2. View

12.

Jagelman D, DECOSSE J, Bussey H . Upper gastrointestinal cancer in familial adenomatous polyposis. Lancet. 1988; 1(8595):1149-51. DOI: 10.1016/s0140-6736(88)91962-9. View

13.

Hadithi M, Heine G, Jacobs M, van Bodegraven A, V Bodegraven A, Mulder C . A prospective study comparing video capsule endoscopy with double-balloon enteroscopy in patients with obscure gastrointestinal bleeding. Am J Gastroenterol. 2006; 101(1):52-7. DOI: 10.1111/j.1572-0241.2005.00346.x. View

14.

Sanders L, Henderson C, Hong M, Barhoumi R, Burghardt R, Carroll R . Pro-oxidant environment of the colon compared to the small intestine may contribute to greater cancer susceptibility. Cancer Lett. 2004; 208(2):155-61. DOI: 10.1016/j.canlet.2003.12.007. View

15.

Halfdanarson T, McWilliams R, Donohue J, Quevedo J . A single-institution experience with 491 cases of small bowel adenocarcinoma. Am J Surg. 2010; 199(6):797-803. DOI: 10.1016/j.amjsurg.2009.05.037. View

16.

Maguire A, Sheahan K . Primary small bowel adenomas and adenocarcinomas-recent advances. Virchows Arch. 2018; 473(3):265-273. DOI: 10.1007/s00428-018-2400-7. View

17.

Masselli G, Di Tola M, Casciani E, Polettini E, Laghi F, Monti R . Diagnosis of Small-Bowel Diseases: Prospective Comparison of Multi-Detector Row CT Enterography with MR Enterography. Radiology. 2015; 279(2):420-31. DOI: 10.1148/radiol.2015150263. View

18.

Vanoli A, Grillo F, Guerini C, Neri G, Arpa G, Klersy C . Prognostic Role of Mismatch Repair Status, Histotype and High-Risk Pathologic Features in Stage II Small Bowel Adenocarcinomas. Ann Surg Oncol. 2020; 28(2):1167-1177. PMC: 7801310. DOI: 10.1245/s10434-020-08926-4. View

19.

Aparicio T, Svrcek M, Zaanan A, Beohou E, Laforest A, Afchain P . Small bowel adenocarcinoma phenotyping, a clinicobiological prognostic study. Br J Cancer. 2013; 109(12):3057-66. PMC: 3859950. DOI: 10.1038/bjc.2013.677. View

20.

Dabaja B, Suki D, Pro B, Bonnen M, Ajani J . Adenocarcinoma of the small bowel: presentation, prognostic factors, and outcome of 217 patients. Cancer. 2004; 101(3):518-26. DOI: 10.1002/cncr.20404. View