Primary Small Bowel Adenomas and Adenocarcinomas-recent Advances

Overview

Journal Virchows Arch

Specialties Cell Biology
Molecular Biology
Pathology

Date 2018 Jul 13

PMID 29998424

Citations 10

Authors

Aoife Maguire

Kieran Sheahan

Affiliations

Soon will be listed here.

Abstract

The small intestine represents 75% of the length and 90% of the absorptive surface area of the gastrointestinal tract (GIT), yet only 2% of digestive system cancers occur at this site. Adenocarcinoma accounts for half of small bowel malignancies. There have been a number of important recent advances in our understanding, classification and treatment of small bowel tumours. Over recent years, ampullary tumours have become recognised as a form of small bowel carcinoma, distinct from head of pancreas and lower biliary tract tumours. This is reflected in separate TNM systems and increasing interest in separating intestinal from pancreatobiliary subtypes. The recognition of the importance of microsatellite (MSI) status and the advent of molecular pathology has also changed our approach to these neoplasms.

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