Factors Regulating or Regulated by Myogenic Regulatory Factors in Skeletal Muscle Stem Cells

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2022 May 14

PMID 35563799

Authors

Tomohiko Shirakawa

Takashi Toyono

Asako Inoue

Takuma Matsubara

Tatsuo Kawamoto

Shoichiro Kokabu

Affiliations

Soon will be listed here.

Abstract

MyoD, Myf5, myogenin, and MRF4 (also known as Myf6 or herculin) are myogenic regulatory factors (MRFs). MRFs are regarded as master transcription factors that are upregulated during myogenesis and influence stem cells to differentiate into myogenic lineage cells. In this review, we summarize MRFs, their regulatory factors, such as TLE3, NF-κB, and MRF target genes, including non-myogenic genes such as taste receptors. Understanding the function of MRFs and the physiology or pathology of satellite cells will contribute to the development of cell therapy and drug discovery for muscle-related diseases.

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