The Roles of Ubiquitination in Pathogenesis of Influenza Virus Infection

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 May 14

PMID 35562987

Authors

Eun-Sook Park

Mehrangiz Dezhbord

Ah Ram Lee

Kyun-Hwan Kim

Affiliations

Soon will be listed here.

Abstract

The ubiquitin system denotes a potent post-translational modification machinery that is capable of activation or deactivation of target proteins through reversible linkage of a single ubiquitin or ubiquitin chains. Ubiquitination regulates major cellular functions such as protein degradation, trafficking and signaling pathways, innate immune response, antiviral defense, and virus replication. The RNA sensor RIG-I ubiquitination is specifically induced by influenza A virus (IAV) to activate type I IFN production. Influenza virus modulates the activity of major antiviral proteins in the host cell to complete its full life cycle. Its structural and non-structural proteins, matrix proteins and the polymerase complex can regulate host immunity and antiviral response. The polymerase PB1-F2 of mutated 1918 IAV, adapts a novel IFN antagonist function by sending the DDX3 into proteasomal degradation. Ultimately the fate of virus is determined by the outcome of interplay between viral components and host antiviral proteins and ubiquitination has a central role in the encounter of virus and its host cell.

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References

McAuley J, Kedzierska K, Brown L, Shanks G . Host Immunological Factors Enhancing Mortality of Young Adults during the 1918 Influenza Pandemic. Front Immunol. 2015; 6:419. PMC: 4541073. DOI: 10.3389/fimmu.2015.00419. View

Rudnicka A, Yamauchi Y . Ubiquitin in Influenza Virus Entry and Innate Immunity. Viruses. 2016; 8(10). PMC: 5086625. DOI: 10.3390/v8100293. View

Hu J, Zhang L, Liu X . Role of Post-translational Modifications in Influenza A Virus Life Cycle and Host Innate Immune Response. Front Microbiol. 2020; 11:517461. PMC: 7498822. DOI: 10.3389/fmicb.2020.517461. View

Gao D, Yang Y, Wang R, Zhou X, Diao F, Li M . REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I. PLoS One. 2009; 4(6):e5760. PMC: 2684588. DOI: 10.1371/journal.pone.0005760. View

Chen C, Zhuang X . Epsin 1 is a cargo-specific adaptor for the clathrin-mediated endocytosis of the influenza virus. Proc Natl Acad Sci U S A. 2008; 105(33):11790-5. PMC: 2504482. DOI: 10.1073/pnas.0803711105. View

Guan Z, Liu D, Mi S, Zhang J, Ye Q, Wang M . Interaction of Hsp40 with influenza virus M2 protein: implications for PKR signaling pathway. Protein Cell. 2011; 1(10):944-55. PMC: 4875119. DOI: 10.1007/s13238-010-0115-x. View

Chen Z, Sun L . Nonproteolytic functions of ubiquitin in cell signaling. Mol Cell. 2009; 33(3):275-86. DOI: 10.1016/j.molcel.2009.01.014. View

Welchman R, Gordon C, Mayer R . Ubiquitin and ubiquitin-like proteins as multifunctional signals. Nat Rev Mol Cell Biol. 2005; 6(8):599-609. DOI: 10.1038/nrm1700. View

Conenello G, Palese P . Influenza A virus PB1-F2: a small protein with a big punch. Cell Host Microbe. 2007; 2(4):207-9. DOI: 10.1016/j.chom.2007.09.010. View

10.

Liu Y, Olagnier D, Lin R . Host and Viral Modulation of RIG-I-Mediated Antiviral Immunity. Front Immunol. 2017; 7:662. PMC: 5206486. DOI: 10.3389/fimmu.2016.00662. View

11.

Varga Z, Grant A, Manicassamy B, Palese P . Influenza virus protein PB1-F2 inhibits the induction of type I interferon by binding to MAVS and decreasing mitochondrial membrane potential. J Virol. 2012; 86(16):8359-66. PMC: 3421771. DOI: 10.1128/JVI.01122-12. View

12.

Liu B, Zhang M, Chu H, Zhang H, Wu H, Song G . The ubiquitin E3 ligase TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitination. Nat Immunol. 2016; 18(2):214-224. DOI: 10.1038/ni.3641. View

13.

Sieczkarski S, Whittaker G . Influenza virus can enter and infect cells in the absence of clathrin-mediated endocytosis. J Virol. 2002; 76(20):10455-64. PMC: 136567. DOI: 10.1128/jvi.76.20.10455-10464.2002. View

14.

Gack M, Shin Y, Joo C, Urano T, Liang C, Sun L . TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature. 2007; 446(7138):916-920. DOI: 10.1038/nature05732. View

15.

Kirui J, Mondal A, Mehle A . Ubiquitination Upregulates Influenza Virus Polymerase Function. J Virol. 2016; 90(23):10906-10914. PMC: 5110180. DOI: 10.1128/JVI.01829-16. View

16.

Lamotte L, Tafforeau L . How Influenza A Virus NS1 Deals with the Ubiquitin System to Evade Innate Immunity. Viruses. 2021; 13(11). PMC: 8619935. DOI: 10.3390/v13112309. View

17.

Munoz-Moreno R, Martinez-Romero C, Garcia-Sastre A . Induction and Evasion of Type-I Interferon Responses during Influenza A Virus Infection. Cold Spring Harb Perspect Med. 2020; 11(10). PMC: 8485741. DOI: 10.1101/cshperspect.a038414. View

18.

Liu B, Jin J, Li Y . Ubiquitination modification: critical regulation of IRF family stability and activity. Sci China Life Sci. 2020; 64(6):957-965. PMC: 7607542. DOI: 10.1007/s11427-020-1796-0. View

19.

Heaton S, Borg N, Dixit V . Ubiquitin in the activation and attenuation of innate antiviral immunity. J Exp Med. 2015; 213(1):1-13. PMC: 4710203. DOI: 10.1084/jem.20151531. View

20.

Banerjee I, Miyake Y, Nobs S, Schneider C, Horvath P, Kopf M . Influenza A virus uses the aggresome processing machinery for host cell entry. Science. 2014; 346(6208):473-7. DOI: 10.1126/science.1257037. View