Induction and Evasion of Type-I Interferon Responses During Influenza A Virus Infection

Overview

Journal Cold Spring Harb Perspect Med

Specialty General Medicine

Date 2020 Jul 15

PMID 32661015

Citations 13

Authors

Raquel Munoz-Moreno

Carles Martinez-Romero

Adolfo Garcia-Sastre

Affiliations

Soon will be listed here.

Abstract

Influenza A viruses (IAVs) are contagious pathogens and one of the leading causes of respiratory tract infections in both humans and animals worldwide. Upon infection, the innate immune system provides the first line of defense to neutralize or limit the replication of invading pathogens, creating a fast and broad response that brings the cells into an alerted state through the secretion of cytokines and the induction of the interferon (IFN) pathway. At the same time, IAVs have developed a plethora of immune evasion mechanisms in order to avoid or circumvent the host antiviral response, promoting viral replication. Herein, we will review and summarize already known and recently described innate immune mechanisms that host cells use to fight IAV viral infections as well as the main strategies developed by IAVs to overcome such powerful defenses during this fascinating virus-host interplay.

Citing Articles

Regulation of interferon alpha production by the MAGUK-family protein CASK under H5N1 infection.

Huang J, Sung P, Hsieh S Front Immunol. 2025; 15():1513713.

PMID: 39850902 PMC: 11754051. DOI: 10.3389/fimmu.2024.1513713.

H7N7 viral infection elicits pronounced, sex-specific neuroinflammatory responses .

Gabele L, Bochow I, Rieke N, Sieben C, Michaelsen-Preusse K, Hosseini S Front Cell Neurosci. 2024; 18:1444876.

PMID: 39171200 PMC: 11335524. DOI: 10.3389/fncel.2024.1444876.

Roles and functions of IAV proteins in host immune evasion.

Rashid F, Xie Z, Li M, Xie Z, Luo S, Xie L Front Immunol. 2023; 14:1323560.

PMID: 38152399 PMC: 10751371. DOI: 10.3389/fimmu.2023.1323560.

IFNλ: balancing the light and dark side in pulmonary infection.

Antos D, Alcorn J mBio. 2023; 14(4):e0285022.

PMID: 37278532 PMC: 10470512. DOI: 10.1128/mbio.02850-22.

Warmer ambient air temperatures reduce nasal turbinate and brain infection, but increase lung inflammation in the K18-hACE2 mouse model of COVID-19.

Dumenil T, Le T, Rawle D, Yan K, Tang B, Nguyen W Sci Total Environ. 2022; 859(Pt 1):160163.

PMID: 36395835 PMC: 9659553. DOI: 10.1016/j.scitotenv.2022.160163.

References

Kato H, Takeuchi O, Sato S, Yoneyama M, Yamamoto M, Matsui K . Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature. 2006; 441(7089):101-5. DOI: 10.1038/nature04734. View

Huang I, Bailey C, Weyer J, Radoshitzky S, Becker M, Chiang J . Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus. PLoS Pathog. 2011; 7(1):e1001258. PMC: 3017121. DOI: 10.1371/journal.ppat.1001258. View

Nemeroff M, Barabino S, Li Y, Keller W, KRUG R . Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs. Mol Cell. 1998; 1(7):991-1000. DOI: 10.1016/s1097-2765(00)80099-4. View

DCunha J, Ramanujam S, WAGNER R, Witt P, KNIGHT Jr E, Borden E . In vitro and in vivo secretion of human ISG15, an IFN-induced immunomodulatory cytokine. J Immunol. 1996; 157(9):4100-8. View

Ferguson L, Olivier A, Genova S, Epperson W, Smith D, Schneider L . Pathogenesis of Influenza D Virus in Cattle. J Virol. 2016; 90(12):5636-5642. PMC: 4886773. DOI: 10.1128/JVI.03122-15. View

Thomis D, Samuel C . Mechanism of interferon action: autoregulation of RNA-dependent P1/eIF-2 alpha protein kinase (PKR) expression in transfected mammalian cells. Proc Natl Acad Sci U S A. 1992; 89(22):10837-41. PMC: 50437. DOI: 10.1073/pnas.89.22.10837. View

Manz B, Dornfeld D, Gotz V, Zell R, Zimmermann P, Haller O . Pandemic influenza A viruses escape from restriction by human MxA through adaptive mutations in the nucleoprotein. PLoS Pathog. 2013; 9(3):e1003279. PMC: 3610643. DOI: 10.1371/journal.ppat.1003279. View

Ebner P, Versteeg G, Ikeda F . Ubiquitin enzymes in the regulation of immune responses. Crit Rev Biochem Mol Biol. 2017; 52(4):425-460. PMC: 5490640. DOI: 10.1080/10409238.2017.1325829. View

ciampor F, Bayley P, Nermut M, Hirst E, Sugrue R, Hay A . Evidence that the amantadine-induced, M2-mediated conversion of influenza A virus hemagglutinin to the low pH conformation occurs in an acidic trans Golgi compartment. Virology. 1992; 188(1):14-24. DOI: 10.1016/0042-6822(92)90730-d. View

10.

Iwai A, Shiozaki T, Kawai T, Akira S, Kawaoka Y, Takada A . Influenza A virus polymerase inhibits type I interferon induction by binding to interferon beta promoter stimulator 1. J Biol Chem. 2010; 285(42):32064-74. PMC: 2952208. DOI: 10.1074/jbc.M110.112458. View

11.

Lakadamyali M, Rust M, Zhuang X . Endocytosis of influenza viruses. Microbes Infect. 2004; 6(10):929-36. PMC: 2715838. DOI: 10.1016/j.micinf.2004.05.002. View

12.

Kuriakose T, Kanneganti T . Regulation and functions of NLRP3 inflammasome during influenza virus infection. Mol Immunol. 2017; 86:56-64. PMC: 5453821. DOI: 10.1016/j.molimm.2017.01.023. View

13.

Zhang R, Chi X, Wang S, Qi B, Yu X, Chen J . The regulation of autophagy by influenza A virus. Biomed Res Int. 2014; 2014:498083. PMC: 3980786. DOI: 10.1155/2014/498083. View

14.

Twu K, Noah D, Rao P, Kuo R, Krug R . The CPSF30 binding site on the NS1A protein of influenza A virus is a potential antiviral target. J Virol. 2006; 80(8):3957-65. PMC: 1440456. DOI: 10.1128/JVI.80.8.3957-3965.2006. View

15.

Gack M, Shin Y, Joo C, Urano T, Liang C, Sun L . TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature. 2007; 446(7138):916-920. DOI: 10.1038/nature05732. View

16.

Jounai N, Takeshita F, Kobiyama K, Sawano A, Miyawaki A, Xin K . The Atg5 Atg12 conjugate associates with innate antiviral immune responses. Proc Natl Acad Sci U S A. 2007; 104(35):14050-5. PMC: 1955809. DOI: 10.1073/pnas.0704014104. View

17.

Min J, Li S, Sen G, Krug R . A site on the influenza A virus NS1 protein mediates both inhibition of PKR activation and temporal regulation of viral RNA synthesis. Virology. 2007; 363(1):236-43. DOI: 10.1016/j.virol.2007.01.038. View

18.

Bruns A, Horvath C . LGP2 synergy with MDA5 in RLR-mediated RNA recognition and antiviral signaling. Cytokine. 2015; 74(2):198-206. PMC: 4475439. DOI: 10.1016/j.cyto.2015.02.010. View

19.

Venkataraman T, Valdes M, Elsby R, Kakuta S, Caceres G, Saijo S . Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses. J Immunol. 2007; 178(10):6444-55. DOI: 10.4049/jimmunol.178.10.6444. View

20.

Fanning A, Anderson J . PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane. J Clin Invest. 1999; 103(6):767-72. PMC: 408156. DOI: 10.1172/JCI6509. View