Sclerostin is a Promising Therapeutic Target for Oral Inflammation and Regenerative Dentistry

Overview

Journal J Transl Med

Publisher Biomed Central

Specialties Biomedical Engineering
General Medicine

Date 2022 May 13

PMID 35562828

Authors

Chufang Liao

Shanshan Liang

Yining Wang

Ting Zhong

Xiangning Liu

Affiliations

Soon will be listed here.

Abstract

Sclerostin is the protein product of the SOST gene and is known for its inhibitory effects on bone formation. The monoclonal antibody against sclerostin has been approved as a novel treatment method for osteoporosis. Oral health is one of the essential aspects of general human health. Hereditary bone dysplasia syndrome caused by sclerostin deficiency is often accompanied by some dental malformations, inspiring the therapeutic exploration of sclerostin in the oral and dental fields. Recent studies have found that sclerostin is expressed in several functional cell types in oral tissues, and the expression level of sclerostin is altered in pathological conditions. Sclerostin not only exerts similar negative outcomes on the formation of alveolar bone and bone-like tissues, including dentin and cementum, but also participates in the development of oral inflammatory diseases such as periodontitis, pulpitis, and peri-implantitis. This review aims to highlight related research progress of sclerostin in oral cavity, propose necessary further research in this field, and discuss its potential as a therapeutic target for dental indications and regenerative dentistry.

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References

Virdi A, Liu M, Sena K, Maletich J, McNulty M, Ke H . Sclerostin antibody increases bone volume and enhances implant fixation in a rat model. J Bone Joint Surg Am. 2012; 94(18):1670-80. PMC: 3444952. DOI: 10.2106/JBJS.K.00344. View

Balli U, Keles Z, Avci B, Guler S, Cetinkaya B, Keles G . Assessment of periostin levels in serum and gingival crevicular fluid of patients with periodontal disease. J Periodontal Res. 2014; 50(6):707-13. DOI: 10.1111/jre.12254. View

Korn P, Kramer I, Schlottig F, Todtman N, Eckelt U, Burki A . Systemic sclerostin antibody treatment increases osseointegration and biomechanical competence of zoledronic-acid-coated dental implants in a rat osteoporosis model. Eur Cell Mater. 2019; 37:333-346. DOI: 10.22203/eCM.v037a20. View

Taut A, Jin Q, Chung J, Galindo-Moreno P, Yi E, Sugai J . Sclerostin antibody stimulates bone regeneration after experimental periodontitis. J Bone Miner Res. 2013; 28(11):2347-56. DOI: 10.1002/jbmr.1984. View

Tan W, Wong T, Wong M, Lang N . A systematic review of post-extractional alveolar hard and soft tissue dimensional changes in humans. Clin Oral Implants Res. 2012; 23 Suppl 5:1-21. DOI: 10.1111/j.1600-0501.2011.02375.x. View

Staehling-Hampton K, Proll S, Paeper B, Zhao L, Charmley P, Brown A . A 52-kb deletion in the SOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch population. Am J Med Genet. 2002; 110(2):144-52. DOI: 10.1002/ajmg.10401. View

Maillard S, Sicard L, Andrique C, Torrens C, Lesieur J, Baroukh B . Combining sclerostin neutralization with tissue engineering: An improved strategy for craniofacial bone repair. Acta Biomater. 2021; 140:178-189. DOI: 10.1016/j.actbio.2021.11.046. View

Kim J, Kim A, Choi Y, Kim A, Sohn Y, Woo G . Intermittent PTH administration improves alveolar bone formation in type 1 diabetic rats with periodontitis. J Transl Med. 2018; 16(1):70. PMC: 5856320. DOI: 10.1186/s12967-018-1438-2. View

Huang X, Xie M, Xie Y, Mei F, Lu X, Li X . The roles of osteocytes in alveolar bone destruction in periodontitis. J Transl Med. 2020; 18(1):479. PMC: 7733264. DOI: 10.1186/s12967-020-02664-7. View

10.

Gaudio A, Pennisi P, Bratengeier C, Torrisi V, Lindner B, Mangiafico R . Increased sclerostin serum levels associated with bone formation and resorption markers in patients with immobilization-induced bone loss. J Clin Endocrinol Metab. 2010; 95(5):2248-53. DOI: 10.1210/jc.2010-0067. View

11.

Lundquist P . Odontoblast phosphate and calcium transport in dentinogenesis. Swed Dent J Suppl. 2002; (154):1-52. View

12.

Mitsiadis T, Rahiotis C . Parallels between tooth development and repair: conserved molecular mechanisms following carious and dental injury. J Dent Res. 2004; 83(12):896-902. DOI: 10.1177/154405910408301202. View

13.

Tecles O, Laurent P, Zygouritsas S, Burger A, Camps J, Dejou J . Activation of human dental pulp progenitor/stem cells in response to odontoblast injury. Arch Oral Biol. 2005; 50(2):103-8. DOI: 10.1016/j.archoralbio.2004.11.009. View

14.

Liu M, Dai J, Lin Y, Yang L, Dong H, Li Y . Effect of the cyclic stretch on the expression of osteogenesis genes in human periodontal ligament cells. Gene. 2011; 491(2):187-93. DOI: 10.1016/j.gene.2011.09.031. View

15.

Abdalla R, Mitchell R, Ren Y . Non-carious cervical lesions imaged by focus variation microscopy. J Dent. 2017; 63:14-20. DOI: 10.1016/j.jdent.2017.05.001. View

16.

Rhee Y, Allen M, Condon K, Lezcano V, Ronda A, Galli C . PTH receptor signaling in osteocytes governs periosteal bone formation and intracortical remodeling. J Bone Miner Res. 2010; 26(5):1035-46. PMC: 3179307. DOI: 10.1002/jbmr.304. View

17.

Kim J, Lee D, Woo G, Cha J, Bak E, Yoo Y . Osteocytic Sclerostin Expression in Alveolar Bone in Rats With Diabetes Mellitus and Ligature-Induced Periodontitis. J Periodontol. 2015; 86(8):1005-11. DOI: 10.1902/jop.2015.150083. View

18.

Liao C, Ou Y, Wu Y, Zhou Y, Liang S, Wang Y . Sclerostin inhibits odontogenic differentiation of human pulp-derived odontoblast-like cells under mechanical stress. J Cell Physiol. 2019; 234(11):20779-20789. DOI: 10.1002/jcp.28684. View

19.

Brunkow M, Gardner J, Van Ness J, Paeper B, Kovacevich B, Proll S . Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein. Am J Hum Genet. 2001; 68(3):577-89. PMC: 1274471. DOI: 10.1086/318811. View

20.

Li X, Ominsky M, Niu Q, Sun N, Daugherty B, DAgostin D . Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength. J Bone Miner Res. 2008; 23(6):860-9. DOI: 10.1359/jbmr.080216. View