Gold Nanoparticles Based Optical Biosensors for Cancer Biomarker Proteins: A Review of the Current Practices

Overview

Journal Front Bioeng Biotechnol

Date 2022 May 13

PMID 35557858

Authors

Jinghua Tai

Shuang Fan

Siqi Ding

Lishen Ren

Affiliations

Soon will be listed here.

Abstract

Cancer prognosis depends on the early detection of the disease. Gold nanoparticles (AuNPs) have attracted much importance in biomedical research due to their distinctive optical properties. The AuNPs are easy to fabricate, biocompatible, surface controlled, stable, and have surface plasmonic properties. The AuNPs based optical biosensors can intensely improve the sensitivity, specificity, resolution, penetration depth, contrast, and speed of these devices. The key optical features of the AuNPs based biosensors include localized surface plasmon resonance (LSPR), SERS, and luminescence. AuNPs based biomarkers have the potential to sense the protein biomarkers at a low detection level. In this review, the fabrication techniques of the AuNPs have been reviewed. The optical biosensors based on LSPR, SERS, and luminescence are also evaluated. The application of these biosensors for cancer protein detection is discussed. Distinct examples of cancer research that have a substantial impact on both scientific and clinical research are presented.

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References

Liu Y, Fu W, Xu Z, Zhang L, Sun T, Du M . pH-Driven Reversible Assembly and Disassembly of Colloidal Gold Nanoparticles. Front Chem. 2021; 9:675491. PMC: 8116534. DOI: 10.3389/fchem.2021.675491. View

Misek D, Kim E . Protein biomarkers for the early detection of breast cancer. Int J Proteomics. 2011; 2011:343582. PMC: 3195294. DOI: 10.1155/2011/343582. View

Bakirhan N, Ozcelikay G, Ozkan S . Recent progress on the sensitive detection of cardiovascular disease markers by electrochemical-based biosensors. J Pharm Biomed Anal. 2018; 159:406-424. DOI: 10.1016/j.jpba.2018.07.021. View

Bell S, Charron G, Cortes E, Kneipp J, Lamy de la Chapelle M, Langer J . Towards Reliable and Quantitative Surface-Enhanced Raman Scattering (SERS): From Key Parameters to Good Analytical Practice. Angew Chem Int Ed Engl. 2019; 59(14):5454-5462. PMC: 7154527. DOI: 10.1002/anie.201908154. View

Sanders M, Lin Y, Wei J, Bono T, Lindquist R . An enhanced LSPR fiber-optic nanoprobe for ultrasensitive detection of protein biomarkers. Biosens Bioelectron. 2014; 61:95-101. DOI: 10.1016/j.bios.2014.05.009. View

Cabuzu D, Cirja A, Puiu R, Grumezescu A . Biomedical applications of gold nanoparticles. Curr Top Med Chem. 2015; 15(16):1605-13. DOI: 10.2174/1568026615666150414144750. View

Yu Z, Grasso M, Cui X, Silva R, Zhang P . Sensitive and Label-Free SERS Detection of Single-Stranded DNA Assisted by Silver Nanoparticles and Gold-Coated Magnetic Nanoparticles. ACS Appl Bio Mater. 2022; 3(5):2626-2632. DOI: 10.1021/acsabm.9b01218. View

Wang Y, Quinsaat J, Ono T, Maeki M, Tokeshi M, Isono T . Enhanced dispersion stability of gold nanoparticles by the physisorption of cyclic poly(ethylene glycol). Nat Commun. 2020; 11(1):6089. PMC: 7705015. DOI: 10.1038/s41467-020-19947-8. View

Yuan H, Ji W, Chu S, Liu Q, Qian S, Guang J . Mercaptopyridine-Functionalized Gold Nanoparticles for Fiber-Optic Surface Plasmon Resonance Hg Sensing. ACS Sens. 2019; 4(3):704-710. DOI: 10.1021/acssensors.8b01558. View

10.

Ramirez Garcia G, dOrlye F, Richard C, Mignet N, Varenne A . Electrokinetic elucidation of the interactions between persistent luminescent nanoprobes and the binary apolipoprotein-E/albumin protein system. Analyst. 2021; 146(17):5245-5254. DOI: 10.1039/d1an00781e. View

11.

Palermo G, Rippa M, Conti Y, Vestri A, Castagna R, Fusco G . Plasmonic Metasurfaces Based on Pyramidal Nanoholes for High-Efficiency SERS Biosensing. ACS Appl Mater Interfaces. 2021; 13(36):43715-43725. PMC: 8447193. DOI: 10.1021/acsami.1c12525. View

12.

Lomeli-Marroquin D, Medina Cruz D, Nieto-Arguello A, Vernet Crua A, Chen J, Torres-Castro A . Starch-mediated synthesis of mono- and bimetallic silver/gold nanoparticles as antimicrobial and anticancer agents. Int J Nanomedicine. 2019; 14:2171-2190. PMC: 6443225. DOI: 10.2147/IJN.S192757. View

13.

Ouellette M, Masse F, Lefebvre-Demers M, Maestracci Q, Grenier P, Millar R . Insights into gold nanoparticles as a mucoadhesive system. Sci Rep. 2018; 8(1):14357. PMC: 6156509. DOI: 10.1038/s41598-018-32699-2. View

14.

Liu D, Huang X, Wang Z, Jin A, Sun X, Zhu L . Gold nanoparticle-based activatable probe for sensing ultralow levels of prostate-specific antigen. ACS Nano. 2013; 7(6):5568-76. PMC: 3696512. DOI: 10.1021/nn401837q. View

15.

U S D, Fu C, Soh K, Ramaswamy B, Kumar A, Olivo M . Highly sensitive SERS detection of cancer proteins in low sample volume using hollow core photonic crystal fiber. Biosens Bioelectron. 2012; 33(1):293-8. DOI: 10.1016/j.bios.2011.12.056. View

16.

Surinova S, Schiess R, Huttenhain R, Cerciello F, Wollscheid B, Aebersold R . On the development of plasma protein biomarkers. J Proteome Res. 2010; 10(1):5-16. DOI: 10.1021/pr1008515. View

17.

Deng Z, Chen K, Wu C . Improving the SERS signals of biomolecules using a stacked biochip containing FeO/Au nanoparticles and a DC magnetic field. Sci Rep. 2019; 9(1):9566. PMC: 6606591. DOI: 10.1038/s41598-019-45879-5. View

18.

Huang X, Jain P, El-Sayed I, El-Sayed M . Gold nanoparticles: interesting optical properties and recent applications in cancer diagnostics and therapy. Nanomedicine (Lond). 2007; 2(5):681-93. DOI: 10.2217/17435889.2.5.681. View

19.

Wang X, Li G, Chen T, Yang M, Zhang Z, Wu T . Polymer-encapsulated gold-nanoparticle dimers: facile preparation and catalytical application in guided growth of dimeric ZnO-nanowires. Nano Lett. 2008; 8(9):2643-7. DOI: 10.1021/nl080820q. View

20.

Peng N, Hu C, Chiu Y, Yu C, Li C, Sheu J . Detection of Recurrent Cervical Cancer and Prediction of Its Patient Survival with Serum Squamous-Cell Carcinoma-Antigen and 2-[F] Fluoro-2-Deoxy-d-Glucose-Positron Emission Tomography/Computed Tomography. Diagnostics (Basel). 2020; 10(9). PMC: 7555056. DOI: 10.3390/diagnostics10090657. View