High Levels of Platelettolymphocyte Ratio May Predict Reduced Risk of End Stage of Renal Disease in Chinese Patients with MPOANCA Associated Vasculitis

Overview

Journal Zhong Nan Da Xue Xue Bao Yi Xue Ban

Specialty General Medicine

Date 2022 May 11

PMID 35545411

Authors

Li Huang

Chanjuan Shen

Yong Zhong

Joshua D Ooi

Peter J Eggenhuizen

Yaou Zhou

Jinbiao Chen

Ting Wu

Ting Meng

Zhou Xiao

Wei Lin

Rong Tang

Xiang Ao

Xiangcheng Xiao

Qiaoling Zhou

Ping Xiao

Affiliations

Soon will be listed here.

Abstract

Objectives: Platelet-to-lymphocyte ratio (PLR) has recently been investigated as a new inflammatory marker in many inflammatory diseases, including systemic lupus erythematosus and immunoglobulin A vasculitis. However, there were very few reports regarding the clinical role of PLR in patients with anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis. This study was thus undertaken to investigate the relationship between inflammatory response and disease activity in Chinese patients with myeloperoxidase-anti-neutrophil cytoplasmic antibody (MPO-ANCA) associated vasculitis. Furthermore, we evaluated whether PLR predicts the progression of end stage of renal disease (ESRD) and all-cause mortality.

Methods: The clinical, laboratory and pathological data, and the outcomes of MPO-ANCA associated vasculitis patients were collected. The Spearman correlation coefficient was computed to examine the association between 2 continuous variables. Cox regression analysis was used to estimate the association between PLR and ESRD or all-cause mortality.

Results: A total of 190 consecutive patients with MPO-ANCA associated vasculitis were included in this study. Baseline PLR was positively correlated with CRP (=0.333, <0.001) and ESR (=0.218, =0.003). PLR had no obvious correlation with Birmingham Vasculitis Activity Score (BVAS). Patients having PLR≥330 exhibited better cumulative renal survival rates than those having PLR<330 (=0.017). However, there was no significant difference in the cumulative patient survival rates between patients with PLR≥330 and those with PLR<330 at diagnosis (>0.05). In multivariate analysis, PLR is associated with the decreased risk of ESRD (=0.038, HR=0.518, 95% CI 0.278 to 0.963). We did not find an association between PLR with all-cause mortality using multivariate analysis (HR=1.081, 95% CI 0.591 to 1.976, =0.801).

Conclusions: PLR is positively correlated with CRP and ESR. Furthermore, PLR may independently predict the risk of ESRD.

Citing Articles

Lower Platelet-to-Lymphocyte Ratio Was Associated with Poor Prognosis for Newborn Patients in NICU.

Tang Y, Teng Y, Xu L, Xu G, Chen D, Jin X Medicina (Kaunas). 2022; 58(10).

PMID: 36295557 PMC: 9612288. DOI: 10.3390/medicina58101397.

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