Hospital-wide SARS-CoV-2 Antibody Screening of 4840 Staff Members in a University Medical Center in France: a Cross-sectional Study

Overview

Journal BMJ Open

Specialty General Medicine

Date 2022 May 11

PMID 35545377

Authors

Marion Pierson-Marchandise

Sandrine Castelain

Cassandra Chevalier

Etienne Brochot

Jean-Luc Schmit

Momar Diouf

Olivier Ganry

Maxime Gignon

Affiliations

Soon will be listed here.

Abstract

Objectives: Healthcare workers are more likely to be infected by SARS-CoV-2. In order to assess the infectious risk associated with working in a hospital, we sought to estimate the proportion of healthcare professionals infected with SARS-CoV-2 by screening staff in a University Medical Center in France.

Setting: A hospital-wide screening campaign (comprising a serological test and a questionnaire) ran from 18 May to 26 July 2020.

Primary And Secondary Outcome Measures: The seroprevalence rate was analysed in a multivariate analysis according to sociodemographic variables (age, sex and profession), exposure to SARS-CoV-2 and symptoms.

Results: A total of 4840 professionals were included, corresponding to 74.5% of the centre's staff. The seroprevalence rate (95% CI) was 9.7% (7.0% to 12.4%). Contact with a confirmed case of COVID-19 was significantly associated with seropositivity (OR (95% CI: 1.43, (1.15 to 1.78)). The seroprevalence rate was significantly higher among nursing assistants (17.6%) than among other healthcare professionals. The following symptoms were predictive of COVID-19: anosmia (OR (95% CI): 1.55, (1.49 to 1.62)), ageusia (1.21, (1.16 to 1.27)), fever (1.15, (1.12 to 1.18)), myalgia (1.03, (1.01 to 1.06)) and headache (1.03, (1.01 to 1.04)).

Citing Articles

Seroprevalence of SARS-CoV-2 antibodies among healthcare workers in Dutch hospitals after the 2020 first wave: a multicentre cross-sectional study with prospective follow-up.

Recanatini C, GeurtsvanKessel C, Pas S, Broens E, Maas M, van Mansfeld R Antimicrob Resist Infect Control. 2023; 12(1):137.

PMID: 38031155 PMC: 10688070. DOI: 10.1186/s13756-023-01324-x.

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