3(2)-pyridazinone Derivatives: a New Scaffold for Novel Plant Activators

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 May 11

PMID 35540577

Authors

Qinjie Shi

Yanxia Shi

Kang Chang

Jianqin Chen

Zhenjiang Zhao

Weiping Zhu

Yufang Xu

Baoju Li

Xuhong Qian

Affiliations

Soon will be listed here.

Abstract

Due to the emergence of drug resistance, pesticide residue and environmental contamination, it is important to develop novel eco-friendly strategies to protect plants. Among them, plant activators have been gaining more and more attention. Herein, based on SHAFTS method, a new scaffold for novel plant activators was predicted and the discovery and structure-activity relationships of a series of 3(2)-pyridazinone derivatives as novel plant activators were elucidated in detail. The vast majority of compounds exhibited excellent broad-spectrum induced resistance activity against tested diseases but no direct antimicrobial activity . Among them, compound 32 showed excellent efficacy against four pathogens and great potential as new plant activators in crop protection.

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