A Feasible Strategy for Self-assembly of Gold Nanoparticles Dithiol-PEG for Photothermal Therapy of Cancers

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 May 11

PMID 35539587

Authors

Yingjie Fu

Qishuai Feng

Yajing Shen

Mengwei Chen

Chang Xu

Yu Cheng

Xiang Zhou

Affiliations

Soon will be listed here.

Abstract

We designed and explored self-assembled gold nanoparticles (SAGNPs) by introducing dithiol modified polyethylene glycol (PEG) for internanoparticle cross-linking. SAGNPs could enhance uptake into cancer cells and be disintegrated by glutathione (GSH) to achieve tumor microenvironment-activated biodegradation. This assembled structure improved the photothermal effect compared to single gold nanospheres.

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