An Integrated Wearable Microneedle Array for the Continuous Monitoring of Multiple Biomarkers in Interstitial Fluid

Overview

Journal Nat Biomed Eng

Publisher Springer Nature

Specialty Biomedical Engineering

Date 2022 May 9

PMID 35534575

Authors

Farshad Tehrani

Hazhir Teymourian

Brian Wuerstle

Jonathan Kavner

Ravi Patel

Allison Furmidge

Reza Aghavali

Hamed Hosseini-Toudeshki

Christopher Brown

Fangyu Zhang

Kuldeep Mahato

Zhengxing Li

Abbas Barfidokht

Lu Yin

Paul Warren

Nickey Huang

Zina Patel

Patrick P Mercier

Joseph Wang

Affiliations

Soon will be listed here.

Abstract

Implementations of wearable microneedle-based arrays of sensors for the monitoring of multiple biomarkers in interstitial fluid have lacked system integration and evidence of robust analytical performance. Here we report the development and testing of a fully integrated wearable array of microneedles for the wireless and continuous real-time sensing of two metabolites (lactate and glucose, or alcohol and glucose) in the interstitial fluid of volunteers performing common daily activities. The device works with a custom smartphone app for data capture and visualization, comprises reusable electronics and a disposable microneedle array, and is optimized for system integration, cost-effective fabrication via advanced micromachining, easier assembly, biocompatibility, pain-free skin penetration and enhanced sensitivity. Single-analyte and dual-analyte measurements correlated well with the corresponding gold-standard measurements in blood or breath. Further validation of the technology in large populations with concurrent validation of sensor readouts through centralized laboratory tests should determine the robustness and utility of real-time simultaneous monitoring of several biomarkers in interstitial fluid.

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