Harnessing the Power of Leptin: The Biochemical Link Connecting Obesity, Diabetes, and Cognitive Decline

Overview

Journal Front Aging Neurosci

Specialty Geriatrics

Date 2022 May 9

PMID 35527735

Authors

Patricia Grasso

Affiliations

Soon will be listed here.

Abstract

In this review, the current understanding of leptin's role in energy balance, glycemic regulation, and cognitive function is examined, and its involvement in maintaining the homeostatic "harmony" of these physiologies is explored. The effects of exercise on circulating leptin levels are summarized, and the results of clinical application of leptin to metabolic disease and neurologic dysfunction are reviewed. Finally, pre-clinical evidence is presented which suggests that synthetic peptide leptin mimetics may be useful in resolving not only the leptin resistance associated with common obesity and other elements of metabolic syndrome, but also the peripheral insulin resistance characterizing type 2 diabetes mellitus, and the central insulin resistance associated with certain neurologic deficits in humans.

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