Differing Impact of Phosphoglycerate Mutase 1-deficiency on Brown and White Adipose Tissue

Overview

Journal iScience

Publisher Cell Press

Date 2022 May 6

PMID 35521515

Authors

Yohko Yoshida

Ippei Shimizu

Yung-Ting Hsiao

Masayoshi Suda

Goro Katsuumi

Masahide Seki

Yutaka Suzuki

Shujiro Okuda

Tomoyoshi Soga

Tohru Minamino

Affiliations

Soon will be listed here.

Abstract

Brown adipose tissue (BAT) is a metabolically active organ that contributes to the thermogenic response to cold exposure. In addition, other thermogenic cells termed beige adipocytes are generated in white adipose tissue (WAT) by cold exposure. Although activation of brown/beige adipose tissue is associated with mobilization of both glucose and lipids, few studies have focused on the role of glycolytic enzymes in regulating adipose tissue function. We generated mouse models with specific deletion of the glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) from adipose tissue. Deletion of Pgam1 from both BAT and WAT promoted whitening of BAT with beiging of visceral WAT, whereas deletion of Pgam1 from BAT alone led to whitening of BAT without beiging of WAT. Our results demonstrate a potential role of glycolytic enzymes in beiging of visceral WAT and suggest that PGAM1 would be a novel therapeutic target in obesity and diabetes.

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