Biventricular Strain and Strain Rate Impairment Shortly After Surgical Repair of Tetralogy of Fallot in Children: A Case-control Study

Overview

Journal Health Sci Rep

Specialty General Medicine

Date 2022 May 6

PMID 35517373

Authors

Bahar Dehghan

Alireza Ahmadi

Shima Sarfarazi Moghadam

Mohammad Reza Sabri

Mehdi Ghaderian

Chehreh Mahdavi

Mohsen Sedighi

Hamid Bigdelian

Affiliations

Soon will be listed here.

Abstract

Background: Early biventricular dysfunction in repaired tetralogy of Fallot (TOF) children may lead to poor clinical outcomes. We aimed to assess biventricular function in TOF children before and after surgery by speckle tracking echocardiography (STE) and compare them with the controls.

Methods: Twenty repaired TOF children and 20 normal children as controls were assessed by STE. Tricuspid annular plane systolic excursion (TAPSE), left ventricular ejection fraction (LVEF), biventricular strain, and strain rate were compared before and after surgery and between TOF children and controls.

Results: Postoperative LVEF ( = 0.001), strain ( = 0.001), and strain rate ( = 0.001) for left ventricle improved significantly compared to preoperative phase. However, postoperative left ventricular strain ( = 0.05) and strain rate ( = 0.01) in TOF children were significantly impaired compared to controls. Postoperative LVEF was correlated inversely with postoperative strain rate ( = -0.40, = 0.04). Postoperative TAPSE ( = 0.001), strain ( = 0.001), and strain rate ( = 0.001) for right ventricle significantly worsened when compared with the preoperative phase. Moreover, postoperative TAPSE ( = 0.001), strain ( = 0.001), and strain rate ( = 0.01) were significantly impaired compared to controls. Postoperative right ventricular strain rate was correlated significantly with the weight of children ( = 0.48, = 0.02), and postoperative left ventricular strain showed significant correlations with aortic clamp time ( = 0.44, = 0.04) and with ICU stay ( = -0.46, = 0.04).

Conclusion: Despite normal LVEF, TOF children exhibit impaired left ventricular strain and strain rate after surgery. TAPSE, strain, and strain rate for the right ventricle worsen after surgical repair. STE-driven strain can be used to detect early ventricular dysfunction and the associated prognostic implications.

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Letter to the editor regarding article by Dehghan et al.: "Biventricular strain and strain rate impairment shortly after surgical repair of tetralogy of Fallot in children: A case-control study".

Mutluer F, Kardys I, Roos-Hesselink J, van den Bosch A Health Sci Rep. 2022; 5(5):e782.

PMID: 35957966 PMC: 9364430. DOI: 10.1002/hsr2.782.

Biventricular strain and strain rate impairment shortly after surgical repair of tetralogy of Fallot in children: A case-control study.

Dehghan B, Ahmadi A, Sarfarazi Moghadam S, Sabri M, Ghaderian M, Mahdavi C Health Sci Rep. 2022; 5(3):e613.

PMID: 35517373 PMC: 9063058. DOI: 10.1002/hsr2.613.

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